Abstract Title:

Reproductive and developmental toxicities of zinc supplemented rats.

Abstract Source:

Reprod Toxicol. 2010 Oct 25. Epub 2010 Oct 25. PMID: 20977935

Abstract Author(s):

F O Johnson, E T Gilbreath, L Ogden, T C Graham, S Gorham

Article Affiliation:

Department of Pharmacology and Toxicology and Neuroscience Program, B307 Life Sciences Building, Michigan State University, East Lansing, MI 48824, United States.


Reproductive and developmental toxicities of zinc supplementation in F(0) rats and F(1) progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl(2)) at 0.0, 7.5, 15 and 30mg/kg-d. ZnCl(2) treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F(0) females, ZnCl(2) was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F(0) males, ZnCl(2) significantly increased relative liver weight and elevatedγ-GGT. In addition, at birth, F(1) males exhibited, a significant (p<0.05) increase in anogenital distance, whereas ZnCl(2) hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl(2) supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring.

Study Type : Animal Study

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