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Abstract Title:

In vitro inhibitory effects of cirsiliol on IL-6-induced STAT3 activation through anti-inflammatory activity.

Abstract Source:

Bioorg Med Chem Lett. 2019 07 1 ;29(13):1586-1592. Epub 2019 May 2. PMID: 31060888

Abstract Author(s):

Hyung Jin Lim, Hyun Jae Jang, Seon Gyeong Bak, Soyoung Lee, Seung Woong Lee, Kang Min Lee, Seung-Jae Lee, Mun-Chual Rho

Article Affiliation:

Hyung Jin Lim

Abstract:

Many studies have identified and described various medicinal effects of cirsiliol. Here, we investigated the signaling pathway involved in the anti-inflammatory effects of cirsiliol on IL-6-induced activity. Cirsiliol showed no cytotoxicity and inhibited pSTAT3-induced luciferase activity. At the molecular level, cirsiliol suppressed the expression of IL-6-induced inflammatory marker genes such as CRP, IL-1β, ICAM-1 and SOCS3, IL-6-induced activation of Jak2, gp130, STAT3 and ERK and nuclear translocation of STAT3, as measured by PCR, immunofluorescence staining and western blot analysis. However, the interaction between IL-6 and its receptor was not affected by cirsiliol treatment. These results indicate that cirsiliol attenuates IL-6-induced cellular signaling by regulating Jak2 phosphorylation. Therefore, cirsiliol could be a therapeutic agent for IL-6-related inflammatory diseases.

Study Type : In Vitro Study

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Sayer Ji
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