n/a
Abstract Title:

Thymoquinone protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis.

Abstract Source:

J Cell Biochem. 2018 Sep 30. Epub 2018 Sep 30. PMID: 30269355

Abstract Author(s):

Xin Hu, Yuanyuan Liang, Bo Zhao, Yongyi Wang

Article Affiliation:

Xin Hu

Abstract:

Oxidative stress in retinal pigment epithelium (RPE) cells may contribute to the progression of age-related macular degeneration. Thymoquinone (TQ), an active component derived from Nigella sativa, possesses antioxidative effect. However, the role of TQ in RPE cells under oxidative stress condition remains unclear. The present study aimed to examine the protective effect of TQ against hydrogen peroxide (HO)-induced oxidative stress in human RPE cells. Our results showed that TQ improved the cell viability and apoptosis in HO-induced ARPE cells. We also found that the levels of reactive oxygen species and malondialdehyde induced by HOwere reduced after the pretreatment of TQ. In addition, the inhibitory effect of HOon the glutathione (GSH) level and superoxide dismutase activity was markedly attenuated by TQ pretreatment. Moreover, TQ enhanced the activation of Nrf2/heme oxygenase 1 (HO-1) signaling pathway in HO-induced ARPE cells. Knockdown of Nrf2 abolished the protective effect of TQ on HO-induced oxidative damage. These results suggested that TQ protected ARPE cells from HO-induced oxidative stress and apoptosis via the Nrf2/HO-1 signaling pathway.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.