Abstract Title:

Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.

Abstract Source:

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Dec ;118(6):674-83. Epub 2014 Sep 16. PMID: 25457886

Abstract Author(s):

Blake M Warner, Bruce C Casto, Thomas J Knobloch, Brent T Accurso, Christopher M Weghorst

Article Affiliation:

Blake M Warner

Abstract:

OBJECTIVE: To evaluate the preclinical efficacy of topical administration of freeze-dried black raspberries (BRBs) to inhibit the progression of premalignant oral lesions and modulate biomarkers of cancer development in high at-risk mucosa (HARM).

STUDY DESIGN: Hamster cheek pouches (HCPs) were treated with carcinogen for 6 weeks to initiate a HARM microenvironment. Subsequently, right HCPs were topically administered a BRB suspension in short-term or long-term studies. After 12 weeks, squamous cell carcinoma (SCC) multiplicity, SCC incidence, and cell proliferation rates were evaluated. mRNA expression was measuredin short-term treated pouches for selected oral cancer biomarkers.

RESULTS: SCC multiplicity (-41.3%), tumor incidence (-37.1%), and proliferation rate (-6.9%) were reduced in HCPs receiving BRBs. Topical BRBs correlated with an increase in RB1 expression in developing oral lesions.

CONCLUSIONS: Topical BRBs inhibit SCC development when targeted to HARM tissues. These results support the translational role of BRBs to prevent oral cancer development in humans.

Study Type : In Vitro Study

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