Abstract Title:

A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America.

Abstract Source:

Acta Paediatr. 1999 Sep;88(9):953-6. PMID: 10519335

Abstract Author(s):

S M Pueschel, C Romano, P Failla, C Barone, R Pettinato, A Castellano Chiodo, D L Plumari

Article Affiliation:

Child Development Center, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA.


In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down syndrome have celiac disease.

Study Type : Human Study

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