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Article Publish Status: FREE
Abstract Title:

Suppression of Inflammatory Cytokines Expression with Bitter Melon () in TNBS-instigated Ulcerative Colitis.

Abstract Source:

J Transl Int Med. 2020 Sep ;8(3):177-187. Epub 2020 Sep 25. PMID: 33062594

Abstract Author(s):

Asli Semiz, Ozden Ozgun Acar, Hulya Cetin, Gurkan Semiz, Alaattin Sen

Article Affiliation:

Asli Semiz

Abstract:

Background and Objective: This study was aimed to elucidate the molecular mechanism of, along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid (TNBS).

Methods: After the induction of the experimental colitis, the animals were treated with MCh (4 g/kg/day) for 14 consecutive days by intragastric gavage. The colonic tissue expression levels of C-C motif chemokine ligand 17 (CCL-17), interleukin (IL)-1β, IL-6, IL-23, interferon-γ (IFN-γ), nuclear factor kappa B (NF-kB), and tumor necrosis factor-α (TNF-α), were determined at both mRNA and protein levels to estimate the effect of. Besides, colonic specimens were analyzed histopathologically after staining with hematoxylin and eosin.

Results: The body weights from TNBS-instigated colitis rats were found to be significantly lower than untreated animals. Also, the IFN-γ, IL-1β, IL-6, Il-23, TNF-α, CCL-17, and NF-kB mRNA and protein levels were increased significantly from 1.86-4.91-fold and 1.46-5.50-fold, respectively, in the TNBS-instigated colitis group as compared to the control. Both the MCh and prednisolone treatment significantly reduced the bodyweightloss. It also restored the induced colonic tissue levels of IL-1β, IL-6, IFN-γ, and TNF-α to normal levels seen in untreated animals. These results were also supported with the histochemical staining of the colonic tissues from both control and treated animals.

Conclusion: The presented data strongly suggests thathas the anti-inflammatory effect that might be modulated through vitamin D metabolism. It is the right candidate for the treatment of UC as an alternative and complementary therapeutics.

Study Type : Animal Study

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