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Article Publish Status: FREE
Abstract Title:

[6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication.

Abstract Source:

Biomed Res Int. 2021 ;2021:6623400. Epub 2021 Mar 27. PMID: 33855075

Abstract Author(s):

Rahma F Hayati, Cynthia D Better, Dionisius Denis, Amalina G Komarudin, Anom Bowolaksono, Benediktus Yohan, R Tedjo Sasmono

Article Affiliation:

Rahma F Hayati

Abstract:

Chikungunya (CHIK) is a reemerging arboviral disease caused by chikungunya virus (CHIKV) infection. The disease is clinically hallmarked by prolonged debilitating joint pain. Currently, there is no specific antiviral medication nor commercial vaccine available for treatment of the disease, which makes the discovery or development of specific anti-CHIKV compounds a priority. Ginger (Roscoe) is widely known for its various health benefits. The compound [6]-gingerol is the main active ingredient found in ginger. This study sought to determine the potential of [6]-gingerol antiviral activity against CHIKV infection usinghuman hepatocyte HepG2 cells. The antiviral activity mechanism was investigated using direct virucidal and four indirect (pre-, post-, full-, and prevention) treatment assays. [6]-Gingerol showed weak virucidal activity but significant indirect antiviral activity against CHIKV through post- and full treatment with ICof 0.038 mM and 0.031 mM, respectively, without showing cell cytotoxicity. The results indicated that [6]-gingerol inhibits CHIKV infection through suppression of viral replication. Together, this study confirms the potential use of [6]-gingerol for CHIK antiviral compound.

Study Type : In Vitro Study

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