Abstract Title:

Spontaneous regression of mismatch repair-deficient colorectal cancers: Case series.

Abstract Source:

Dig Endosc. 2020 May 16. Epub 2020 May 16. PMID: 32416608

Abstract Author(s):

Takahiro Utsumi, Shin'ichi Miyamoto, Takahiro Shimizu, Kasumi Yokogawa, Yuki Nakanishi, Mitsuhiro Nikaido, Ayako Hirata, Miyu Nishida, Ikuo Aoyama, Tomoko Okuno, Akihiko Yoshizawa, Akihiro Kaneda, Yoshiharu Sakai, Chiharu Kawanami, Hiroshi Seno

Article Affiliation:

Takahiro Utsumi


Spontaneous regression (SR) has been reported in various malignant tumors. However, SR in colorectal cancer (CRC) is particularly rare and the mechanism remains unclear. We here report three cases of CRCs displaying SR, which were experienced at two institutions. Intriguingly, all of these cases displayed the common endoscopic characteristics; superficial elevated lesion accompanied by a central depression (0-IIa + IIc, in the Paris classification), with a nonpolypoid growth, located in the ascending colon. Furthermore, immunohistology of biopsy specimens revealed the lack of DNA mismatch repair proteins within the CRC lesions, suggesting that these were mismatch repair-deficient (dMMR) CRCs. One of the major features of dMMR cancers is an increase in the number of tumor-infiltrating lymphocytes. Thus, the dMMR phenotype might be associated with SR of CRCs through the activation of anti-tumor host immune responses.

Study Type : Human: Case Report

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