Article Publish Status: FREE
Abstract Title:

EphB2 mediates social isolation-induced memory forgetting.

Abstract Source:

Transl Psychiatry. 2020 Nov 9 ;10(1):389. Epub 2020 Nov 9. PMID: 33168800

Abstract Author(s):

Xin-Rong Wu, Yu Zhang, Xian-Dong Liu, Wu-Bo Han, Nan-Jie Xu, Suya Sun

Article Affiliation:

Xin-Rong Wu


Social isolation in adolescence leads to lasting deficits, including emotional and cognitive dysregulation. It remains unclear, however, how social isolation affects certain processes of memory and what molecular mechanisms are involved. In this study, we found that social isolation during the post-weaning period resulted in forgetting of the long-term fear memory, which was attributable to the downregulation of synaptic function in the hippocampal CA1 region mediated by EphB2, a receptor tyrosine kinase which involves in the glutamate receptor multiprotein complex. Viral-mediated EphB2 knockdown in CA1 mimicked the memory defects in group-housed mice, whereas restoration of EphB2 by either viral overexpression or resocialization reversed the memory decline in isolated mice. Taken together, our finding indicates that social isolation gives rise to memory forgetting by disrupting EphB2-mediated synaptic plasticity, which may provide a potential target for preventing memory loss caused by social isolation or loneliness.

Study Type : Animal Study

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Sayer Ji
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