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Article Publish Status: FREE
Abstract Title:

Microbiota, cirrhosis, and the emerging oral-gut-liver axis.

Abstract Source:

JCI Insight. 2017 Oct 5 ;2(19). Epub 2017 Oct 5. PMID: 28978799

Abstract Author(s):

Chathur Acharya, Sinem Esra Sahingur, Jasmohan S Bajaj

Article Affiliation:

Chathur Acharya

Abstract:

Cirrhosis is a prevalent cause of morbidity and mortality, especially for those at an advanced decompensated stage. Cirrhosis development and progression involves several important interorgan communications, and recently, the gut microbiome has been implicated in pathophysiology of the disease. Dysbiosis, defined as a pathological change in the microbiome, has a variable effect on the compensated versus decompensated stage of cirrhosis. Adverse microbial changes, both in composition and function, can act at several levels within the gut (stool and mucosal) and have also been described in the blood and oral cavity. While dysbiosis in the oral cavity could be a source of systemic inflammation, current cirrhosis treatment modalities are targeted toward the gut-liver axis and do not address the oral microbiome. As interventions designed to modulate oral dysbiosis may delay progression of cirrhosis, a better understanding of this process is of the utmost importance. The concept of oral microbiota dysbiosis in cirrhosis is relatively new; therefore, this review will highlight the emerging role of the oral-gut-liver axis and introduce perspectives for future research.

Study Type : Review

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Sayer Ji
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