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Article Publish Status: FREE
Abstract Title:

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer.

Abstract Source:

Cancers (Basel). 2020 08 4 ;12(8). Epub 2020 Aug 4. PMID: 32759728

Abstract Author(s):

Ammad Ahmad Farooqi, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Nada Alaaeddine, Damião Pergentino de Sousa, Baojun Xu, William C Cho

Article Affiliation:

Ammad Ahmad Farooqi

Abstract:

There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone fromwas brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we reviewed andrographolide on cellular pathways regulation including Wnt/β-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.

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