Abstract Title:

Prenylated indole alkaloids and lignans from the flower buds of Tussilago farfara.

Abstract Source:

Fitoterapia. 2020 Sep 19 ;146:104729. Epub 2020 Sep 19. PMID: 32956711

Abstract Author(s):

Xiu-Qing Song, Jia Sun, Jin-Hai Yu, Jun-Sheng Zhang, Jie Bao, Hua Zhang

Article Affiliation:

Xiu-Qing Song


Six new compounds including four prenylated indole alkaloids (1-4) and two lignans (5-6), along with eight known cometabolites (7-14), were isolated from the flower buds of Tussilago farfara. Structures of the new compounds were elucidated by comparison with structurally related known analogues and also by comprehensive spectroscopic analyses. Their absolute configurations were determined by a variety of means including Mosher's method, Marfey's analysis, electronic circular dichroism (ECD) exciton chirality method and ECD calculations. Our bioassays have established that compounds 1 and 2 showed potentα-glucosidase inhibitory activity with ICvalues of 105 ± 4.7 and 35.2 ± 3.2 μM, respectively, while the known 13 and 14 exerted moderate DPPH radical scavenging activity with ICvalues of 45.2 ± 2.9 and 29.2 ± 2.0 μM, respectively.

Study Type : In Vitro Study

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