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Abstract Title:

Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.

Abstract Source:

Curr Drug Deliv. 2020 Oct 27. Epub 2020 Oct 27. PMID: 33109049

Abstract Author(s):

Ayşenur Yazici, Lisa Marinelli, Ivana Cacciatore, Bugrahan Emsen, Piera Eusepi, Giuseppe Di Biase, Antonio Di Stefano, Adil Mardinoğlu, Hasan Türkez

Article Affiliation:

Ayşenur Yazici

Abstract:

BACKGROUND: Essential oils are considered as promising sources of novel anticancer compounds. Carvacrol (CVC), the major constituent of many aromatic plants including oregano and thymus, is endowed with curative properties on different cancers including liver, colon, and lung. Little information is available regarding the potentials of CVC for the treatment of brain cancers, notably glioblastoma multiforme (GBM).

OBJECTIVE: In this work, we investigated, the in vitro effect of CVC codrugs (CVC1-8), synthesized by direct-coupled codrug strategies, on human glioblastoma cell line (U87-MG) for the first time.

METHOD: Cell viability was detected by MTT and LDH assays while expression levels of important genes (such as EGFR, NFKB1A, AKT1, AKT2, and others) associated with GBM and inflammatory pathway were detected by PCR array.

RESULTS: Results showed that CVC1-8 codrugs induced cytotoxicity and positive alterations in molecular responses on U87MG cells. Particularly, important pathways (such as PI3K/PTEN/AKT) involved in the onset and progression of GBM resulted in modulated by CVC3 and CVC8.

CONCLUSION: Our results suggest that CVC3 and CVC8 could be suitable candidates for further investigation to develop new strategies for the prevention and/or treatment of GBM.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032)

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