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Article Publish Status: FREE
Abstract Title:

Association Between PMExposure Level and Primary Open-Angle Glaucoma in Taiwanese Adults: A Nested Case-Control Study.

Abstract Source:

Int J Environ Res Public Health. 2021 Feb 10 ;18(4). Epub 2021 Feb 10. PMID: 33578928

Abstract Author(s):

Han-Yin Sun, Ci-Wen Luo, Yun-Wei Chiang, Kun-Lin Yeh, Yi-Ching Li, Yung-Chung Ho, Shiuan-Shinn Lee, Wen-Ying Chen, Chun-Jung Chen, Yu-Hsiang Kuan

Article Affiliation:

Han-Yin Sun

Abstract:

Primary open-angle glaucoma (POAG) is the most common type of glaucoma. However, little is known about POAG in adults and exposure to air pollution. The current study aims to investigate whether exposure to particulate matter with a mass median aerodynamic diameter of≤2.5 μm (PM) is associated with POAG diagnosis. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008-2013 period. PMconcentration data, collected from the Ambient Air Quality Monitoring Network established by the Environmental Protection Administration of Taiwan, were categorized into four groups according to World Health Organization (WHO) exposure standards for PM. We estimated the odds ratios (ORs) and 95% CIs for risk factors for POAG with logistic regression. The OR of per WHO standard level increase was 1.193 (95% CI 1.050-1.356). Compared with the normal level, the OR of WHO 2.0 level was 1.668 (95% CI 1.045-2.663,<0.05). After excluding confounding risk factors for POAG in this study, we determined that increased PMexposure is related to POAG risk (ORs>1,<0.05). In this study, PMwas an independent factor associated with open-angle glaucoma. Further research is required to better understand the mechanisms connecting PMand open-angle glaucoma.

Study Type : Human Study

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