Abstract Title:

Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile.

Abstract Source:

Eur J Cell Biol. 2016 Apr 6. Epub 2016 Apr 6. PMID: 27083410

Abstract Author(s):

Ana Salomé Pires, Cláudia Raquel Marques, João Carlos Encarnação, Ana Margarida Abrantes, Ana Catarina Mamede, Mafalda Laranjo, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, Maria Filomena Botelho

Article Affiliation:

Ana Salomé Pires


Colorectal cancer is a major health problem worldwide with urgent need for new and effective anti-cancer approaches that allow treating, increasing survival and improving life quality of patients. At pharmacological concentrations, ascorbic acid (AA) exerts a selective cytotoxic effect, whose mechanism of cytotoxicity remains unsolved. It has been suggested that it depends on the production of extracellular hydrogen peroxide, using ascorbate radical as an intermediate. The aim of this study was to evaluate the effects induced by AA in three colon cancer cell lines, as well as, possible cell death mechanisms involved. Our results showed that pharmacological concentrations of AA induce anti-proliferative, cytotoxic and genotoxic effects on three colon cancer cell lines under study. We also found that AA can induce cell death by an increment of oxidative stress, but also mediating a ROS-independent mechanism, as observed in LS1034 cells. This work explores AA anti-tumoral effects and highlights its applicability in the treatment of CC, underlying the importance of proceeding to clinical trials.

Study Type : In Vitro Study

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