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Abstract Title:

Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.

Abstract Source:

Exp Mol Pathol. 2020 Jan 7 ;113:104374. Epub 2020 Jan 7. PMID: 31917966

Abstract Author(s):

Ellen Cristina Rivas Leonel, Silvana Gisele Pegorin Campos, Carolina Marques Baraldi Bedolo, Luiz Henrique Alves Guerra, Patrícia Simone Leite Vilamaior, Marilia Freitas Calmon, Paula Rahal, Christiani Andrade Amorim, Sebastião Roberto Taboga

Article Affiliation:

Ellen Cristina Rivas Leonel

Abstract:

The endocrine disruptive effects caused by bisphenol A (BPA) are well known. Despite this, to date, evaluation of its long term effects is limited, meaning that there is still much to be unveiled in terms of alterations caused by perinatal exposure to BPA. Our aim was to determine if perinatal exposure to two different doses of BPA causes long term morphological and molecular alteration effects in the mammary gland (MG). We evaluated MG from Mongolian gerbil offspring exposed perinatally (during gestation and lactation) to 50 or 5000μg/kg/day BPA. At 90 days of age the animals were subjected to a single dose of N-nitroso-N-methylurea in order to mimic a carcinogenic environment. At 6 months of age, animals in estrous were euthanized for morphological evaluation of the MGs. The MG architecture presented considerable changes interms of detached epithelial cells, inflammation, glandular hyperplasia, and collagen fiber deposition. Furthermore, a higher index of epithelial cell proliferation was detected in comparison to the intact control group. In addition, we verified a higher molecular expression of EZH2 in the vehicle treated group, indicating that corn oil applied alone can alter the expression of this epigenetic biomarker. In conclusion, BPA perinatal exposure promotes significant changes in glandular cytoarchitecture and increases glandular epithelium proliferation rate, leading to the retention of stem-like properties. This event could compromise the fate and differentiation potential of mammary epithelium.

Study Type : Animal Study

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