Abstract Title:

Serum vitamin D and hippocampal gray matter volume in schizophrenia.

Abstract Source:

Psychiatry Res. 2015 Jun 24. Epub 2015 Jun 24. PMID: 26163386

Abstract Author(s):

Venkataram Shivakumar, Sunil V Kalmady, Anekal C Amaresha, Dania Jose, Janardhanan C Narayanaswamy, Sri Mahavir Agarwal, Boban Joseph, Ganesan Venkatasubramanian, Vasanthapuram Ravi, Matcheri S Keshavan, Bangalore N Gangadhar

Article Affiliation:

Venkataram Shivakumar


Disparate lines of evidence including epidemiological and case-control studies have increasingly implicated vitamin D in the pathogenesis of schizophrenia. Vitamin D deficiency can lead to dysfunction of the hippocampus - a brain region hypothesized to be critically involved in schizophrenia. In this study, we examined for potential association between serum vitamin D level and hippocampal gray matter volume in antipsychotic-naïve or antipsychotic-free schizophrenia patients (n=35). Serum vitamin D level was estimated using 25-OH vitamin D immunoassay. Optimized voxel-based morphometry was used to analyze 3-Tesla magnetic resonance imaging (MRI) (1-mm slice thickness). Ninety-seven percent of the schizophrenia patients (n=34) had sub-optimal levels of serum vitamin D (83%, deficiency; 14%, insufficiency). A significant positive correlation was seen between vitamin D and regional gray matter volume in the right hippocampus after controlling for age, years of education and total intracranial volume (Montreal Neurological Institute (MNI) coordinates: x=35, y=-18, z=-8; t=4.34 pFWECorrected=0.018). These observations support a potential role of vitamin D deficiency in mediating hippocampal volume deficits, possibly through neurotrophic, neuroimmunomodulatory and glutamatergic effects.

Study Type : Human Study

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