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Abstract Title:

Nephroprotective effect of persimmon leaves (L.f.) against CCl-induced renal toxicity in Swiss Albino rats.

Abstract Source:

Drug Chem Toxicol. 2021 Jan 31:1-9. Epub 2021 Jan 31. PMID: 33522322

Abstract Author(s):

Abdelaaty A Shahat, Riaz Ullah, Ali S Alqahtani, Heba M Hassanein, Husseiny A Husseiny, Nahla M Mohammed, Rashed N Herqash

Article Affiliation:

Abdelaaty A Shahat

Abstract:

L.f. fruit and leaves are traditionally used for the treatment of hypertension, angina, internal hemorrhage, antithrombotic and anti-inflammatory effects.In the current study, the protective effects of ethyl acetate (Per-1),-butanol (Per-2), and aqueous (Per-3) fractions ofleaves against carbon tetrachloride (CCl) induced nephrotoxicity in Swiss albino rats were tested. Animal were divided into nine groups; each group consists of six animals. The groups were : group I was untreated and kept as control, group II was treated with CClonly, group III (silymarin with CCl); group IV (Per-1 100 mg/kg with CCl);group V (Per-1 200 mg/kg with CCl); group VI (Per-2 100 mg/kg with CCl); group VII (Per-2 200 mg/kg with CCl); group VIII (Per-3 100 mg/kg with CCl); and group IX (Per-3 200 mg/kg with CCl). Silymarin was used as standard drug. All tested fractions were found active (except Per-1 at low dose of 100 mg/kg) with significant value ( < 0.001) compared to CClonly group. Serum creatinine, malondialdehyde (MDA), and uric acid were significantly ( < 0.001) lowered in group VII-IX as compared to CClonly group. Similarly, total protein (TP) and non-protein sulfhydryls(NP-SH) level in kidney tissues were significantly ( < 0.001) elevated in the same groups compared to CClonly group. Further to check the cardio-protective potential, biochemical parameters such as LDH, creatine kinase, TP, MDA, and NP-SH levels in myocardial tissues were also estimated.These findings confirmed that the n-butanol and aqueous fractions are active and recommended for further bioactive phytoconstituents screening. Repeated column chromatography on silica gel G and sephadex-LH-20 of the active n-butanol fraction, four flavonoids were isolated. Based on the spectroscopic NMR data, compounds were identified as kaempferol (), quercetin (), astragalin (, and rutin ().

Study Type : Animal Study

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