Abstract Title:

Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models.

Abstract Source:

Future Med Chem. 2018 Aug 10. Epub 2018 Aug 10. PMID: 30095283

Abstract Author(s):

Wei Hou, Siyi Hu, Zhenzhong Su, Qi Wang, Guangping Meng, Tingting Guo, Jie Zhang, Peng Gao

Article Affiliation:

Wei Hou


AIM: Acute lung injury is a common clinical syndrome associated with significant morbidity. Myricetin has been demonstrated to inhibit inflammation in a variety of diseases. In this study, we aimed to investigate the protective effects of myricetin on inflammation in lipopolysaccharide-stimulated RAW 264.7 cells and lipopolysaccharide-induced lung injury model. Results/methodology: In this study, we detected the anti-inflammatory effects of myricetin by ELISA, RT-PCR and Western blot, respectively. Myricetin significantly inhibited the production of the proinflammatory cytokines in vitro and in vivo. It exerted an anti-inflammatory effect through suppressing the NF-κB p65 and AKT activation in NF-κB pathway and JNK, p-ERK and p38 in MAPK signaling pathway.

CONCLUSION: Myricetin alleviated acute lung injury by inhibiting macrophage activation, and inhibited inflammation in vitro and in vivo. It may be a potential therapeutic candidate for the prevention of inflammatory diseases.

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Sayer Ji
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