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Article Publish Status: FREE
Abstract Title:

polysaccharides protect mice from hyperuricaemia through promoting kidney excretion of uric acid and inhibiting liver xanthine oxidase.

Abstract Source:

Pharm Biol. 2020 Dec ;58(1):944-949. PMID: 32946701

Abstract Author(s):

Xin Yu, Lu Zhang, Ping Zhang, Jia Zhi, Ruinan Xing, Lianqi He

Article Affiliation:

Xin Yu

Abstract:

CONTEXT: L. (Solanaceae) polysaccharides (LBPs) are important active constituents that have demonstrated kidney protection.

OBJECTIVE: This study investigated the effect of LBPs on hyperuricaemia and explored the underlying mechanism in mice.

MATERIALS AND METHODS: Thirty-six C57BL/6 mice were randomly divided into the control group, hyperuricaemia group, allopurinol group (5 mg/kg) and three LBP groups (n = 6). The LBP groups were treated orally with LBPs at 50, 100 and 200 mg/kg body weight for 7 days. We examined the levels of serum uric acid (S) and urinary uric acid (U), as well as xanthine oxidase (XOD) activities. mRNA and protein were quantified by quantitative real-time PCR and Western blotting, respectively.

RESULTS: LBPs treatment (100 and 200 mg/kg) significantly reduced the Slevels to 4.83 and 4.48 mg/dL, and markedly elevated the Ulevels to 4.68 and 5.18 mg/dL ( < 0.05), respectively, while significantly increased the mRNA and protein expression levels of renal organic anti-transporter 1 (OAT1) and organic anti-transporter 3 (OAT3), and markedly decreased the levels of glucose transporter 9 (GLUT9) ( < 0.05). Additionally, the serum XOD activities were reduced to 31.5 and 31.1 mU/mL, and the liver XOD activities were reduced to 80.6 and 75.6 mU/mL after treatment with 100 and 200 mg/kg LBPs ( < 0.01), respectively.

DISCUSSION AND CONCLUSIONS: This study demonstrated the potential role of LBPs in reducing the uric acid level in hyperuricemic mice. A border study population should be evaluated. These results are valuable for the development of new anti-hyperuricaemia agents from LBPs.

Study Type : Animal Study

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