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Abstract Title:

GG reverses mortality of neonatal mice againstchallenge.

Abstract Source:

Toxicol Res (Camb). 2019 May 1 ;8(3):361-372. Epub 2019 Feb 5. PMID: 31160970

Abstract Author(s):

Aman Kumar Naik, Uday Pandey, Raktim Mukherjee, Sohini Mukhopadhyay, Subhayan Chakraborty, Arindam Ghosh, Palok Aich

Article Affiliation:

Aman Kumar Naik

Abstract:

Pathogenic infection is one of the major causes of death in newborns. Antibiotic based therapies are still the major mode of treatment for infection. Increased usage of antibiotics leads to selective evolution of microorganisms and causes diseases in adulthood. Attempts to develop alternatives to antibiotics did not yield much success. A recent viable trend is to identify novel probiotics that could alleviate problems associated with over usage of antibiotics. We screened three differentspecies to establish their efficacy in neonates in protecting againstchallenge. The methodologies employed are metagenomics, metabonomics, transcriptional profiling, molecular assays and behavioral studies. Among the three probiotics used, onlyGG (LGG) treatment of the neonates resulted in rescuing of 80% of the-infected mice. We have shown that LGG (MTCC #1408) can preventmediated infection in neonates. In the current report, results from histopathology, gene expression, neutrophil infiltration, metabolite and metataxonomic profiling, and protein level data suggested that LGG treatment of the neonates enhanced anti-inflammatory cytokine expression and increased the gut barrier function. The current report establishes the potential use of LGG in clinical intervention of infectious diseases.

Study Type : Animal Study

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