n/a
Abstract Title:

ZS2058 andGG Use Different Mechanisms to PreventInfection.

Abstract Source:

Front Microbiol. 2019 ;10:299. Epub 2019 Feb 20. PMID: 30842764

Abstract Author(s):

Junsheng Liu, Zhennan Gu, Fanfen Song, Hao Zhang, Jianxin Zhao, Wei Chen

Article Affiliation:

Junsheng Liu

Abstract:

Pathogen-induced infectious diseases pose great threats to public health. Accordingly, many studies have investigated effective strategies targeting pathogenic infections. We previously reported the preventive effects ofZS2058 (ZS2058) andGG (LGG) againstspp. in a murine model. Here, we compared the mechanisms underlying the preventive effects of thesestrains. Notably, reduced C-reactive protein levels were observed with both ZS2058 and LGG, which suggests abrogated anti-infection and inflammatory responses. ZS2058 more efficiently reduced the pathogenicity ofby increasing the level of propionic acid in feces and production of mucin 2 in the mouse colon and activity through the interleukin (IL)-23/IL-22 and IL-23/IL-17 pathways. Meanwhile, LGG more strongly alleviated gut inflammation, as indicated by changes in the levels of tissue necrosis factor (TNF)-α, IL-10 and myeloperoxidase (MPO) in infected mice. Moreover, both ZS2058 and LGG restored the levels of interferon (INF)-γ, a cytokine suppressed by, albeit through different pathways. Our results demonstrate that ZS2058 and LGG preventinfection via different mechanisms.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.