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Article Publish Status: FREE
Abstract Title:

Kefir: A protective dietary supplementation against viral infection.

Abstract Source:

Biomed Pharmacother. 2021 Jan ;133:110974. Epub 2020 Nov 11. PMID: 33186795

Abstract Author(s):

Reham Samir Hamida, Ashwag Shami, Mohamed Abdelaal Ali, Zakiah Nasser Almohawes, Afrah E Mohammed, Mashael Mohammed Bin-Meferij

Article Affiliation:

Reham Samir Hamida

Abstract:

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a recently discovered coronavirus termed 'severe acute respiratory syndrome coronavirus 2' (SARS-CoV-2). Several scholars have tested antiviral drugs and compounds to overcome COVID-19. 'Kefir' is a fermented milk drink similar to a thin yogurt that is made from kefir grains. Kefir and its probiotic contents can modulate the immune system to suppress infections from viruses (e.g., Zika, hepatitis C, influenza, rotaviruses). The antiviral mechanisms of kefir involve enhancement of macrophage production, increasing phagocytosis, boosting production of cluster of differentiation-positive (CD4), CD8, immunoglobulin (Ig)Gand IgAB cells, T cells, neutrophils, as well as cytokines (e.g., interleukin (IL)-2, IL-12, interferon gamma-γ). Kefir can act as an anti-inflammatory agent by reducing expression of IL-6, IL-1, TNF-α, and interferon-γ. Hence, kefir might be a significant inhibitor of the 'cytokine storm' that contributes to COVID-19. Here, we review several studies with a particular emphasis on the effect of kefir consumption and their microbial composition against viral infection, as well as discussing the further development of kefir as a protective supplementary dietary against SARS-CoV-2 infection via modulating the immune response.

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