Article Publish Status: FREE
Abstract Title:

Hepatoprotective Effects of Standardized Extracts from an Ancient Italian Apple Variety (Mela Rosa dei Monti Sibillini) against Carbon Tetrachloride (CCl)-Induced Hepatotoxicity in Rats.

Abstract Source:

Molecules. 2020 Apr 15 ;25(8). Epub 2020 Apr 15. PMID: 32326503

Abstract Author(s):

Hasan Yousefi-Manesh, Ahmad Reza Dehpour, Sedighe Ansari-Nasab, Sara Hemmati, Mohammad Amin Sadeghi, Reza Hashemi Shahraki, Samira Shirooie, Seyed Mohammad Nabavi, Joice G Nkuimi Wandjou, Stefania Sut, Giovanni Caprioli, Stefano Dall'Acqua, Filippo Maggi

Article Affiliation:

Hasan Yousefi-Manesh


The aim of this research was to examine the effect of the hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple cultivar from central Italy (Mela Rosa dei Monti Sibillini) on CCl-induced hepatotoxicity in rats. Phytoconstituents were determined by liquid chromatography-mass spectrometry (LC-MS) analysis showing an abundance of proanthocyanidins and flavonol derivatives together with the presence of annurcoic acid in APE. Wistar rats received APE/APP (30 mg/kg oral administration) for three days before CClinjection (2 mL/kg intraperitoneal once on the third day). Treatment with both APE and APP prior to CClinjection significantly decreased the serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) compared to the CClgroup. Besides, pretreatment with APE reversed the CCleffects on superoxide dismutase (SOD), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and interleukin-1beta (IL-1β) levels in liver tissue in rats and reduced tissue damage as shown in hematoxylin and eosin staining. These results showed that this ancient Italian apple is worthy of use in nutraceuticals and dietary supplements to prevent and/or protect against liver disorders.

Study Type : Animal Study
Additional Links
Substances : Apple
Pharmacological Actions : Hepatoprotective : CK(5098) : AC(2264)

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