Abstract Title:

Biochemical, behavioural and quantitative alterations in cerebellum of Swiss albino mice following irradiation and its modulation by Grewia asiatica.

Abstract Source:

Int J Radiat Biol. 2009 Sep;85(9):787-95. PMID: 19657863

Abstract Author(s):

Rashmi Sisodia, Smita Singh

Article Affiliation:

Radiation Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India. rashsisodia@yahoo.co.in


PURPOSE: To study the biochemical, quantitative histopathological and behavioural changes after 5 Gy whole body irradiation and its modulation by supplementation of Grewia asiatica extract (GAE) on male Swiss albino mice up to 30 days.

MATERIALS AND METHODS: For this, healthy mice from an inbred colony were divided into five groups: (i) Control (vehicle treated); (ii) GAE treated--mice in this group were orally supplemented with GAE (700 mg/kg body weight (bw)/day) once daily for 15 consecutive days; (iii) Irradiated mice; (iv) GAE + irradiated--mice in this group were orally supplemented GAE for 15 days (once a day) prior to irradiation; and (v) Irradiated + GAE--mice in this group were administered GAE orally for 15 days (once a day) consequently after irradiation.

RESULTS: Marked radiation induced changes in the amount of cerebellar lipid peroxidation (LPO), Glutathione (GSH), protein, nucleic acids and histopathological changes could be significantly (p<0.001) ameliorated specially at later intervals by supplementation of GAE prior to and post irradiation. Radiation induced deficits in learning and memory were also significantly (p<0.001) ameliorated.

CONCLUSION: The result of present study showed that prior/post-supplementation of G. asiatica has radioprotective potential as well as neuroprotective properties against the radiation.

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