Abstract Title:

Grape seed proanthocyanidin extract suppresses oxidative stress in the rat pancreas of type-1 diabetes.

Abstract Source:

Arch Physiol Biochem. 2021 Mar 11:1-13. Epub 2021 Mar 11. PMID: 33703969

Abstract Author(s):

Sanna Rajasekhar, Muthangi V V Subramanyam, Sambe Asha Devi

Article Affiliation:

Sanna Rajasekhar


AIM: This study aimed to elucidate the effects of grape seed proanthocyanidin extract (GSPE) on oxidative stress (OS), antioxidant enzymes, free radicals and cytokines in the pancreas of T1DM rats.

METHODS: Two-month-old Wistar rats were assigned to the control (CON), CON + GSPE (CON + PA), diabetics (STZ, 60 mg/kg b.w.), diabetes + GSPE (STZ + PA), diabetes + insulin (STZ + INS, 3 U/day) and diabetics + GSPE and INS (STZ + INS + PA) groups. GSPE (75 mg/kg b.w.) was administered daily either alone or with INS for 8 weeks.

RESULTS: Glutathione was lowest in diabetics while it increased in the STZ + INS + PA ( < .001) group, similar to catalase activity ( < .05). Hydrogen peroxide, superoxide and lipid peroxidation increased with iNOS, TNF-α and IL-1β in the diabetic pancreases, while GSPE decreased ( < .001). Further, reduced β-cells/islet number was improved in diabetics ( < .001) with treatment.

CONCLUSION: This study suggests that GSPE with INS is effective in minimising OS and pancreatic degeneration in T1DM rats.

Study Type : Animal Study

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