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Article Publish Status: FREE
Abstract Title:

Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress.

Abstract Source:

Biomol Ther (Seoul). 2015 Mar ;23(2):165-73. Epub 2015 Mar 1. PMID: 25767685

Abstract Author(s):

Susara Ruwan Kumara Madduma Hewage, Mei Jing Piao, Ki Cheon Kim, Ji Won Cha, Xia Han, Yung Hyun Choi, Sungwook Chae, Jin Won Hyun

Article Affiliation:

Susara Ruwan Kumara Madduma Hewage

Abstract:

Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.

Study Type : In Vitro Study

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Sayer Ji
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