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Article Publish Status: FREE
Abstract Title:

Ferulic acid suppresses interleukin-1β-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1α signaling pathway.

Abstract Source:

Immun Inflamm Dis. 2021 Jun 2. Epub 2021 Jun 2. PMID: 34078001

Abstract Author(s):

Kewei Du, Xuchen Fang, Ziqiang Li

Article Affiliation:

Kewei Du

Abstract:

BACKGROUND: Interleukin-1β (IL-1β) is involved in osteoarthritis pathogenesis and mediates a series of toxic processes including the production of matrix metalloproteinase and inflammatory regulators which are suppressed by activation of silent information regulator 1 (SIRT1). We aimed to determine the effects of ferulicacid (FA) on IL-1β-induced osteoarthritis chondrocyte degeneration.

METHODS: We examined the effects of FA on osteoarthritis chondrocyte viability and SIRT1 activation. The impact of FA on IL-1β-induced osteoarthritis chondrocyte toxicity was determined by prostaglandin E2 (PGE), nitrite, IL-6, components of the extracellular matrix, and markers of oxidative stress. Finally, we determined whether these effects were mediated through SIRT1 by inhibiting SIRT1 activity using SIRT1 inhibitor Sirtinol.

RESULTS: We found that FA activated SIRT1/AMPK/PGC-1α signaling pathway and attenuated IL-1β-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE, nitrite, Collagen I, Runx-2, MMP-1, MMP-3, and MMP-13, enhancing Collagen II and Aggrecan expression and inhibiting oxidative stress. Inhibition of SIRT1 by Sirtinol attenuated the protective effects of FA.

CONCLUSION: Our findings reveal that FA prevents IL-1β-induced osteoarthritis chondrocyte toxicity, which suggests that FA may be a potential therapy for osteoarthritis and warrants further investigation for its clinical application.

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