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Abstract Title:

Exercise Training as Therapy for Cancer-Induced Cardiac Cachexia.

Abstract Source:

Trends Mol Med. 2018 08 ;24(8):709-727. Epub 2018 Jul 3. PMID: 29980479

Abstract Author(s):

J M M Antunes, Rita M P Ferreira, Daniel Moreira-Gonçalves

Article Affiliation:

J M M Antunes

Abstract:

Cancer-induced cardiac cachexia is an insidious syndrome with a dramatic impact on a patient's quality of life and survival. Since exercise training provides several cardiovascular benefits in both physiological and pathological conditions (e.g., athletes and patients with heart failure, respectively), its use as a preventive and/or therapeutic tool for cancer-induced cardiac cachexia has been hypothesized. Existing evidence on the effects of exercise training in this particular setting is limited, but points towards a beneficial outcome. We report the current knowledge on cancer-induced cardiac cachexia and discuss the molecular pathways that may be modulated by exercise training in this setting, providing insights into possible future roads of study, namely in stem cell research and cardiac regeneration.

Study Type : Review
Additional Links
Therapeutic Actions : Exercise : CK(4855) : AC(736)
Pharmacological Actions : Anti-Cachexic Agents : CK(79) : AC(26)

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Sayer Ji
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