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Abstract Title:

Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mice with Lewis Lung Carcinoma.

Abstract Source:

Bull Exp Biol Med. 2020 Jul ;169(3):378-382. Epub 2020 Aug 4. PMID: 32749562

Abstract Author(s):

E A Safonova, K A Lopatina, T G Razina, E P Zueva, A M Gur'ev, M V Belousov

Article Affiliation:

E A Safonova

Abstract:

One of prospective methods for immunotherapy of tumors is modulation via immunological checkpoints, specifically, via the PD-1(CD279)/PD-L1(CD274) system. Interactions between tumor cell receptor (CD279) and the ligand on lymphocytes (CD274) leads to lymphocyte inactivation, which allows tumor escape from the immune control. Experiments on C57BL/6 mice with Lewis lung carcinoma demonstrate the possibility of reducing the expression of CD279 and CD274 on the peripheral blood and tumor tissue lymphocytes under the effects of Tussilago farfara L. polysaccharides. This phenomenon can underlie the antitumor and antimetastatic effects of these substances.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Anti-metastatic : CK(1972) : AC(1481)

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Sayer Ji
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