Abstract Title:

Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats.

Abstract Source:

Braz J Cardiovasc Surg. 2019 Jul 31. Epub 2019 Jul 31. PMID: 31364342

Abstract Author(s):

Hui Wu, Weiyu Chang, Yanglin Deng, Xinli Chen, Yongli Ding, Xuesong Li, Liang Dong

Article Affiliation:

Hui Wu


OBJECTIVE: To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity.

METHODS: In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention.

RESULTS: Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group.

CONCLUSION: Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.

Study Type : Animal Study

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Sayer Ji
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