Abstract Title:

Constituents from Apium graveolens and their anti-inflammatory effects.

Abstract Source:

J Asian Nat Prod Res. 2017 Nov ;19(11):1079-1086. Epub 2017 Oct 3. PMID: 28971709

Abstract Author(s):

Li-Han Zhu, Tian-Hui Bao, Yue Deng, Hua Li, Li-Xia Chen

Article Affiliation:

Li-Han Zhu


A phthalide glycoside, (3R, 4R)-4-O-β-D-glucopyranosyl-senkyunolide (1), and a megastigmane glycoside, (6S, 7R)-3-oxo-megastigma-4, 8-dien-7-O-β-D-glucoside (2), along with two known aglycones (3-4), were isolated from the 70% EtOH extract of fresh whole grass of Apium graveolens L. Their structures were elucidated by extensive spectroscopic analysis. All of these compounds were tested for their inhibitory effects on nitric oxide (NO) production in the RAW 264.7 macrophages. Among them, compounds 3 and 4 showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC50 values of24.0 ± 2.1 μM and 28.6 ± 2.4 μM, respectively.

Study Type : In Vitro Study

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