Article Publish Status: FREE
Abstract Title:

Combined extract of Moringa oleifera and Centella asiatica modulates oxidative stress and senescence in hydrogen peroxide-induced human dermal fibroblasts.

Abstract Source:

Turk J Biol. 2018 ;42(1):33-44. Epub 2018 Feb 15. PMID: 30814868

Abstract Author(s):

Elly Ezlinda Abdul Hisam, Mohd Salleh Rofiee, Aina Mardhia Khalid, Ahmad Firdaus Jalaluddin, Mohd Izwan Mohamad Yusof, Muhd Hanis Idris, Salfarina Ramli, Richard Johari James, Wee Jack Yoeng, Teh Lay Kek, Mohd Zaki Salleh

Article Affiliation:

Elly Ezlinda Abdul Hisam


Moringa oleifera Lam. and Centella asiatica (L.) Urb. leaves have been previously reported to exhibit antioxidant activity. The objective of the present study is to determine the in vitro antioxidant activity of the combined extracts of M. oleifera and C. asiatica (TGT-PRIMAAGE) and its effect on hydrogen peroxide (H 2O2)-induced oxidative stress in human dermal fibroblasts. TGTPRIMAAGE acted on the mechanism of hydrogen transfer as it showed scavenging activity in the DPPH assay. This is due to the presence of phenolics and flavonoids in TGT-PRIMAAGE. TGT-PRIMAAGE effectively reduced cellular generation of reactive oxygen species induced by H O2. The activities of superoxide dismutase and catalase were also increased in cells treated with TGT-PRIMAAGE. 2 Treatment with TGT-PRIMAAGE showed significant reduction (P<0.05) in the number of senescent cells. Significant reduction (P<0.05) of malondialdehyde was also seen in cells treated with TGT-PRIMAAGE. The p53 protein level was reduced in TGT-PRIMAAGEtreated cells, which indicates its potential in protecting the cells from oxidative stress induced by H2O2.

Study Type : In Vitro Study

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