Article Publish Status: FREE
Abstract Title:

Phototherapy promotes healing of cutaneous wounds in undernourished rats.

Abstract Source:

An Bras Dermatol. 2014 Nov-Dec;89(6):899-904. PMID: 25387494

Abstract Author(s):

Saulo Nani Leite, Thiago Antônio Moretti de Andrade, Daniela dos Santos Masson-Meyers, Marcel Nani Leite, Chukuka S Enwemeka, Marco Andrey Cipriani Frade

Article Affiliation:

Saulo Nani Leite


BACKGROUND: Various studies have shown that phototherapy promotes the healing of cutaneous wounds.

OBJECTIVE: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats.

METHODS: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated. In the two treated groups, two 8-mm punch wounds made on the dorsum of each rat were irradiated three times per week with 3 J/cm2 sq cm of combined 660 and 890 nm light; wounds in the other groups were not irradiated. Wounds were evaluated with digital photography and image analysis, either on day 7 or day 14, with biopsies obtained on day 14 for histological studies.

RESULTS: Undernourishment retarded the mean healing rate of the undernourished sham wounds (p<0.01), but not the undernourished Light emission diode treated wounds, which healed significantly faster (p<0.001) and as fast as the two nourished groups. Histological analysis showed a smaller percentage of collagen in the undernourished sham group compared with the three other groups, thus confirming our photographic image analysis data.

CONCLUSION: Phototherapy reverses the adverse healing effects of undernourishment. Similar beneficial effects may be achieved in patients with poor nutritional status.

Study Type : Animal Study

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