n/a
Abstract Title:

Protective effects of chebulic acid fromRetz. against-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells.

Abstract Source:

Food Sci Biotechnol. 2019 Apr ;28(2):555-562. Epub 2018 Sep 27. PMID: 30956868

Abstract Author(s):

Hye-Lim Jung, Sung-Yong Yang, Min Cheol Pyo, Chung-Oui Hong, Mi-Hyun Nam, Jin-Won Lee, Kwang-Won Lee

Article Affiliation:

Hye-Lim Jung

Abstract:

Although chebulic acid isolated fromhas diverse biological effects, its effects on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and the expression of downstream genes have not been elucidated. The purpose of this research is to investigate the hepatoprotective mechanism of chebulic acid against oxidative stress produced by-butyl hydroperoxide (-BHP) in liver cells. The treatment with chebulic acid attenuated cell death in-BHP-induced HepG2 liver cells and increased intracellular glutathione content, upregulated the activity of heme oxygenase-1, and also increased the translocation of Nrf2 into the nucleus and Nrf2 target gene expression in a dose-dependent manner. The exposure of chebulic acid activated the phosphorylation of mitogen-activated protein kinases. The overall result is that chebulic acid has cytoprotective effect on-BHP-induced hepatotoxicity in HepG2 cells through Nrf2-mediated antioxidant enzymes.

Study Type : In Vitro Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.