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Article Publish Status: FREE
Abstract Title:

Chance to rein in a cancer--Spontaneous regression of lung carcinoma (1988-2018): a 30-year perspective.

Abstract Source:

Int J Clin Exp Pathol. 2020 ;13(5):1190-1196. Epub 2020 May 1. PMID: 32509094

Abstract Author(s):

Jingyao Zhang, Haijuan Wang, Chunxiao Li, Haili Qian

Article Affiliation:

Jingyao Zhang

Abstract:

BACKGROUND: Spontaneous regression of tumor is an extremely rare phenomenon in the oncology field and even rarer for lung cancer. However, the underlying mechanism is poorly understood. Summarizing the available clinical information and the supposed mechanism shed new light on lung cancer therapy strategies in the new era of immunotherapy.

SUMMARY: We conducted a PubMed search using the retrieval tactics ("Lung Neoplasms"[Mesh]) AND"Neoplasm Regression, Spontaneous"[Mesh] for reports from 1988 to January 2018, and all references in the relevant literature were subsequently investigated for relevance. Using the criteria of Everson and Cole, 14 cases were finally defined as spontaneous regression and were reviewed in the research. Key messages: The information regarding patient characteristics, treatments, and follow-up has been summarized. In this review, we found that spontaneous lung cancer regression cases fall into two categories including: (1) neurologic disorders in 6 cases, half of whom suffered with paraneoplastic neurological syndromes (PNS) and (2) immunological reactions in 7 cases. Getting data on more spontaneous regression cases and more detailed information will definitely help us understand the mechanism for the body's surveillance system-cancer balance, creating a big chance to increase cancer immunotherapy.

Study Type : Review

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Sayer Ji
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