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Article Publish Status: FREE
Abstract Title:

The Role of Cashew (L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease.

Abstract Source:

Antioxidants (Basel). 2020 Jun 10 ;9(6). Epub 2020 Jun 10. PMID: 32532064

Abstract Author(s):

Roberta Fusco, Rosalba Siracusa, Alesso Filippo Peritore, Enrico Gugliandolo, Tiziana Genovese, Ramona D'Amico, Marika Cordaro, Rosalia Crupi, Giuseppina Mandalari, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola

Article Affiliation:

Roberta Fusco

Abstract:

Osteoarthritis is a progressive joint disease characterized by the activation of different molecular mediators, including proinflammatory cytokines, reactive oxygen species, metalloproteinases and nociceptive mediators.L. is a medicinal plant with anti-oxidative and anti-inflammatory properties. In this study we evaluate the effects of cashew nuts (fromL.) oral administration on an experimental model of painful degenerative joint disease. Monosodium iodoacetate (MIA) was intraarticularly injected, and cashew nuts were orally administered three times per week for 21 days, starting the third day after MIA injection. Nociception was evaluated by a Von Frey filament test, and motor function by walking track analysis at 3, 7, 14 and 21 days after osteoarthritis. Histological and biochemical alteration were examined at the end of the experiment. Cashew nuts administration reduced pain-like behavior and showed antioxidant activities, restoring biochemical serum parameters: glutathione (GSH), catalase (CAT) levels, glutathione peroxidase (GPx) activity and lipid peroxidation. Moreover, cashew nuts ameliorated radiographic and histological alteration, resulting in decreased cartilage degradation, pro-inflammatory cytokines and metalloproteinases levels and mast cells recruitment. Our results demonstrated that the oral assumption of cashew nuts counteracts the inflammatory and oxidative process involved in osteoarthritis.

Study Type : Animal Study

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