Article Publish Status: FREE
Abstract Title:

Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells.

Abstract Source:

Genet Mol Res. 2015 Apr 10 ;14(2):2986-93. Epub 2015 Apr 10. PMID: 25966062

Abstract Author(s):

J C Zheng, S Q Qi, L Yang, Y Y Ma, K R Dong, H T Zhu, S B Yang, T Xu, S Zheng, X M Xiao

Article Affiliation:

J C Zheng


Bisphenol A (BPA) is an industrial contaminant and is reported to be a risk factor associated with the development of tumors. In our previous studies, we have shown that BPA promoted the growth of SK-N-SH human neuroblastoma cells and increased their invasion and metastasis. In this study, we further investigated the effects of BPA and 17β-estradiol (E2) on the stem cell-like cells from SK-N-SH cells. Detection of stem cell markers, proliferation assay, and clonogenic analysis showed that the side-population (SP) of SK-N-SH cells had properties similar to those of stem cells. BPA or E2 exposure decreased the percentage of SP cellsand the expression of stem cell-marker proteins. BPA and E2 promoted the growth of non-SP cells to a greater extent than of SP cells; in addition, they significantly increased the growth of SP cells. Thus, BPA has effects on stem cell-like cells, which induce tumor formation, and thus, BPA is an environmental factor that plays an important role in the development of neuroblastoma.

Study Type : Human In Vitro

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Sayer Ji
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