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Abstract Title:

Beneficial effect ofon olanzapine-induced weight gain and metabolic changes.

Abstract Source:

J Diabetes Metab Disord. 2021 Jun ;20(1):41-48. Epub 2021 Jan 6. PMID: 34178822

Abstract Author(s):

Mrityunjaya B Ullagaddi, B M Patil, Pukar Khanal

Article Affiliation:

Mrityunjaya B Ullagaddi

Abstract:

Aim: The present study aimed to investigate the effect of(ZO) extract on weight gain, food intake, locomotor activity, and lipid and glucose metabolism in olanzapine-treated rats.

Methods: The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were divided into six groups containing six animals in each. Three doses of extract (100, 200, and 400 mg/kg, p.o.) were co-administered with olanzapine 2 mg/kg i.p for 21 days. Bodyweight and food intake were recorded at the interval of three days and locomotor activity once a week. At the end of the study oral glucose tolerance test was performed followed by the estimation of lipid profile.

Results: Co-administration of hydroalcoholic extract of ZO with olanzapine ameliorated olanzapine-induced weight gain and hyperphagia. Similarly, ZO extract also improved pancreaticβ-cell function and glucose and lipid metabolism.

Conclusions: ZO extract ameliorated olanzapine-induced weight gain and hyperphagia by improving pancreaticβ-cell functions and lipid metabolism.

Study Type : Animal Study

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