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Article Publish Status: FREE
Abstract Title:

Anti-Migration and Invasion Effects of Astaxanthin against A172 Human Glioblastoma Cell Line.

Abstract Source:

Asian Pac J Cancer Prev. 2020 Jul 1 ;21(7):2029-2033. Epub 2020 Jul 1. PMID: 32711429

Abstract Author(s):

Tanapan Siangcham, Pornpun Vivithanaporn, Kant Sangpairoj

Article Affiliation:

Tanapan Siangcham

Abstract:

OBJECTIVES: The study was to investigate anti-migration and invasion effects of astaxanthin (ATX), a natural carotenoid derivative distributed in marine environments, against A172 human glioblastoma cells.

MATERIALS AND METHODS: Cell viability after ATX treatment was measured by MTT assays. Tumor cell migration and invasion were observed by scratch and Boyden chamber assays, respectively. Expression of MMP-2 and activity of MMP-9 were observed by immunoblotting and gelatin zymography, respectively.

RESULTS: ATX up to 150µM was not toxic to A172 cells at 48 h post-treatment. In contrast, ATX at 50 and 100 µM significantly decreased migration and invasion of A172 cells at 24 and 48 h post-treatment. Metastatic-reducing effect of ATX is associated with the reduction of MMP-2 and MMP-9 expressions in a dose-dependentmanner.

CONCLUSION: This finding indicated that ATX has anti-migration and invasion effects against human glioblastoma cells and might be applicable for the protection against metastasis of glioblastoma.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-metastatic : CK(1972) : AC(1481)

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