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Abstract Title:

Antiviral and Cytotoxic Activity of Different Plant Parts of Banana (Musa spp.).

Abstract Source:

Viruses. 2020 05 15 ;12(5). Epub 2020 May 15. PMID: 32429324

Abstract Author(s):

Sujogya Kumar Panda, Ana Hortência Fonsêca Castro, Ramin Saleh Jouneghani, Pieter Leyssen, Johan Neyts, Rony Swennen, Walter Luyten

Article Affiliation:

Sujogya Kumar Panda

Abstract:

Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic properties. Different parts such as leaf, pseudostem and corm, collected separately and extracted with four different solvents (hexane, acetone, ethanol, and water), were tested for in vitro antiviral activity against Chikungunya virus (CHIKV), enterovirus 71 (EV71), and yellow fever virus (YFV). Extracts prepared with acetone and ethanol from leaf parts of several cultivars exhibited strong (ECaround 10μg/mL) anti-CHIKV activity. Interestingly, none of the banana plant extracts (concentration 1-100 µg/mL) were active against EV71. Activity against YFV was restricted to two cultivars: Namwa Khom-Pseudostem-Ethanol (5.9 ± 5.4), Namwa Khom-Corm-Ethanol (0.79 ± 0.1) and Fougamou-Corm-Acetone (2.5± 1.5). In most cases, the cytotoxic activity of the extracts was generally 5- to 10-fold lower than the antiviral activity, suggesting a reasonable therapeutic window.

Study Type : In Vitro Study

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