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Article Publish Status: FREE
Abstract Title:

Antioxidant and Anti-Obesity Activities ofExtract through Alleviation of Lipid Accumulation on 3T3-L1 Adipocytes.

Abstract Source:

J Microbiol Biotechnol. 2020 Jan 28 ;30(1):21-30. PMID: 31838799

Abstract Author(s):

Dae-Hye Choi, Joon-Hee Han, Keun-Hyung Yu, Min Hong, Sun-Yeop Lee, Ka-Hee Park, Soo-Ung Lee, Tae-Hyung Kwon

Article Affiliation:

Dae-Hye Choi

Abstract:

Natural products are widely used due to their various biological activities which include antiinflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPARγ, C/EBPα) and lipogenesis-related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-κB, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidantthat can prevent obesityassociated disorders.

Study Type : In Vitro Study

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