n/a
Article Publish Status: FREE
Abstract Title:

Antibiofilm Activity of Heather and Manuka Honeys and Antivirulence Potential of Some of Their Constituents on the DsbA1 Enzyme of.

Abstract Source:

Antibiotics (Basel). 2020 Dec 15 ;9(12). Epub 2020 Dec 15. PMID: 33334017

Abstract Author(s):

Oscar Shirlaw, Zara Billah, Baraa Attar, Lisa Hughes, Rana M Qasaymeh, Veronique Seidel, Georgios Efthimiou

Article Affiliation:

Oscar Shirlaw

Abstract:

Heather honey was tested for its effect on the formation of biofilms by,,,,,andin comparison with Manuka honey. At 0.25 mg/mL, Heather honey inhibited biofilm formation in,,,and, but promoted the growth ofandbiofilms. Manuka honey inhibited biofilm formation in,, and,,and, but promotedbiofilm formation. Molecular docking with Autodock Vina was performed to calculate the predictive binding affinities and ligand efficiencies of Manuka and Heather honey constituents for PaDsbA1, the main enzyme controlling the correct folding of virulence proteins in. A number of constituents, including benzoic acid and methylglyoxal, present in Heather and/or Manuka honey, revealed high ligand efficiencies for the target enzyme. This helps support, to some extent, the decrease inbiofilm formation observed for such honeys.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.