Abstract Title:

Anti-Inflammatory and Photoaging-Protective Effects ofthrough Inhibition of AP-1 and NF-[Formula: see text] B Pathways.

Abstract Source:

Am J Chin Med. 2020 ;48(8):1895-1913. Epub 2020 Dec 10. PMID: 33308098

Abstract Author(s):

Chaoran Song, Deok Jeong, Yo Han Hong, Wan Yi Li, Sang Woo Lee, Mohammad Amjad Hossain, Amani Taamalli, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho

Article Affiliation:

Chaoran Song


is a beneficial edible plant with a number of biological activities like anti-inflammatory, anti-oxidant, antithrombic, antihyperglycemic, and anti-ischemic activities. The mechanisms behind the antiphotoaging and anti-inflammatory effects ofare not fully understood. To investigate how an ethanol extract of(Oe-EE) exerts these effects, we explored its activities in human keratinocytes and dermal fibroblasts. We assessed the anti-oxidant effects of Oe-EE via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2[Formula: see text]-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays and measured the expression levels of matrix metalloproteinases (MMPs), cyclooxygenase-2, interleukin (IL)-6, tumor necrosis factor (TNF)-[Formula: see text], and moisturizing factors. Antiphotoaging and anti-inflammatory mechanisms of Oe-EE were explored by assessing signaling molecule activation via immunoblotting. Oe-EE treatment decreased the mRNA expression level of MMPs, cyclooxygenase-2, IL-6, and TNF-[Formula: see text] and restored type I collagen, filaggrin, and sirtuin 1 expression in UVB-irradiated cells. Furthermore, Oe-EE inhibited the activities of several activator protein 1 regulatory enzymes, including extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), and inhibited nuclear factor (NF)-[Formula: see text]B pathway signaling proteins. Therefore, our results indicate that Oe-EE has photoaging-protective and anti-inflammatory effects.

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