Article Publish Status: FREE
Abstract Title:

Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway.

Abstract Source:

Sci Rep. 2020 10 22 ;10(1):18119. Epub 2020 Oct 22. PMID: 33093618

Abstract Author(s):

Heon-Su Kim, Jung-Soo Suh, Yoon-Kwan Jang, Sang-Hyun Ahn, Ganesan Raja, Jin-Chul Kim, Youngmi Jung, Sang Hoon Jung, Tae-Jin Kim

Article Affiliation:

Heon-Su Kim


Persimmon leaves are known to have some beneficial effects, including ROS elimination, lipid circulation, and neuronal protection. However, their anti-cancer properties and the underlying mechanisms remain unclear. Herein, we show that treatment with the ethanol extract of persimmon, Diospyros kaki, leaves (EEDK) induces cancer cell death and inhibits cell proliferation. Using fluorescence resonance energy transfer (FRET) technology with genetically-encoded biosensors, we first found that EEDK stimulates a PDGFR-Rac signaling cascade in live cells. Moreover, we found that downstream of the PDGFR-Rac pathway, JNKs are activated by EEDK. In contrast, JNK-downstream inhibitors, such as CoCl2, T-5224, and pepstatin A, attenuated EEDK-induced cell death. Thus, we illustrate that the PDGFR-Rac-JNK signaling axis is triggered by EEDK, leading to cancer cell death, suggesting the extract of persimmon leaves may be a promising anti-cancer agent.

Study Type : In Vitro Study

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