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Article Publish Status: FREE
Abstract Title:

Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model.

Abstract Source:

Pharmaceuticals (Basel). 2021 Feb 8 ;14(2). Epub 2021 Feb 8. PMID: 33567513

Abstract Author(s):

Eunkuk Park, Chang Gun Lee, Seung Hee Yun, Seokjin Hwang, Hyoju Jeon, Jeonghyun Kim, Subin Yeo, Hyesoo Jeong, Seong-Hoon Yun, Seon-Yong Jeong

Article Affiliation:

Eunkuk Park

Abstract:

Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from(CO) extract to screen for anti-arthritic effects. A single component, loganin, was identified as a candidate. The CO extract and loganin inhibited the expression of factors associated with cartilage degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte inflammation. In addition, prostaglandin and collagenase levels were reduced following treatment of IL-1β-induced chondrocytes with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse model, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin reduced DMM-induced osteophyte formation. These results indicate that loganin has protective effects in DMM-induced mice.

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