Punicalagin

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36 Diseases Researched for Punicalagin
NameACCKFocus
Hyperglycemia110Locked
Oxidative Stress58Locked
Lipopolysaccharide-Induced Toxicity36Locked
Infertility: Male24Locked
Inflammation34Locked
Staphylococcus aureus infection33Locked
Alzheimer's Disease22Locked
Brain Inflammation 12Locked
Cachexia12Locked
Cervical Cancer22Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide12Locked
Endothelial Dysfunction12Locked
Hypertension: Pulmonary12Locked
Hypoxia12Locked
Kidney Damage: Chemically-Induced12Locked
Memory Disorders12Locked
Myocardial Ischemia12Locked
Salmonella Infections12Locked
Advanced Glycation End products (AGE)11Locked
Air Pollution Linked Toxicity11Locked
Cancers: All11Locked
DNA damage11Locked
Diabetes Mellitus: Type 2: Prevention11Locked
Hepatitis B 11Locked
Herpes Simplex Virus Type 111Locked
High Cholesterol11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Liver Cancer11Locked
Methicillin-resistant Staphylococcus aureus11Locked
Neurodegenerative Diseases11Locked
Nonalcoholic fatty liver disease (NAFLD) 11Locked
Ovarian Cancer11Locked
Placenta Diseases11Locked
Pregnancy Complications11Locked
Prostate Cancer11Locked
Staphylococcal Infections11Locked
39 Pharmacological Actions Researched for Punicalagin
NameACCKFocus
Antioxidants1116Locked
Anti-Inflammatory Agents710Locked
Hypoglycemic Agents110Locked
Anti-Apoptotic35Locked
Cyclooxygenase 2 Inhibitors35Locked
Nrf2 activation35Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor24Locked
Antiproliferative 33Locked
Chemopreventive33Locked
Hepatoprotective23Locked
Interleukin-6 Downregulation23Locked
Anti-Infective Agents12Locked
Antimicrobial22Locked
Antiviral Agents22Locked
Cardioprotective12Locked
Catalase Up-Regulation12Locked
Fertility Agents12Locked
Gastroprotective12Locked
Heme oxygenase-1 inducer12Locked
Interferon Gamma Reducer12Locked
Interleukin-1 beta downregulation12Locked
Interleukin-10 downregulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor22Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
NF-kappaB Inhibitor12Locked
Neuroprotective Agents22Locked
Renoprotective12Locked
Superoxide Dismutase Up-regulation12Locked
Angiogenesis Inhibitors11Locked
Anti-Angiogenic11Locked
Anti-Bacterial Agents11Locked
Anti-metastatic11Locked
Anticholesteremic Agents11Locked
Apoptotic11Locked
Chemotherapeutic11Locked
Cytoprotective11Locked
DNA Repair Up-regulation11Locked
Nitric Oxide Inhibitor11Locked
Prostaglandin PGE2 downregulation11Locked

View the Evidence:
69 Abstracts with Punicalagin Research

[+]

Pomegranate juice confers a lower glycemic response on a high-glycemic index food.Oct 10, 2017

Pubmed Data : Am J Clin Nutr. 2017 Oct 11. Epub 2017 Oct 11. PMID: 29021286
Article Published Date : Oct 10, 2017
Study Type : Human Study
Additional Links
Substances : Pomegranate, Punicalagin
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers.Mar 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Mar 16 ;11(3). Epub 2019 Mar 16. PMID: 30884808
Article Published Date : Mar 15, 2019
Study Type : Human Study
Additional Links
Substances : Hydroxytyrosol, Punicalagin
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Punicalagin and EGCG can rescue keratinocyte viability and attenuate the inflammatory responses of cells due to airborne particles.Mar 21, 2018

Pubmed Data : Skin Pharmacol Physiol. 2018 Mar 22 ;31(3):134-143. Epub 2018 Mar 22. PMID: 29566388
Article Published Date : Mar 21, 2018
Study Type : Human In Vitro
Additional Links
Substances : EGCG (Epigallocatechin gallate), Punicalagin
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jun 2 ;9(6). Epub 2020 Jun 2. PMID: 32498245
Article Published Date : Jun 01, 2020
Study Type : Human In Vitro
Additional Links
Substances : Punicalagin
Diseases : Eye Damage, Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

A new possible mechanism by which punicalagin protects against liver injury induced by type 2 diabetes mellitus.Nov 06, 2019

Pubmed Data : J Agric Food Chem. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31698901
Article Published Date : Nov 06, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Diabetes Mellitus: Type 2, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

By promoting fertility and eliminating oxidative stress and inflammation, Punicalagin may be a useful nutrient for the treatment of infertility.Jan 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian J Androl. 2016 Jan 12. Epub 2016 Jan 12. PMID: 26763544
Article Published Date : Jan 11, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Infertility: Male, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Fertility Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses in rats fed a high-fat diet.Nov 12, 2019

Pubmed Data : Food Funct. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31720661
Article Published Date : Nov 12, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Pomegranate Polyphenols, Punicalagin, Urolithin A
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Punicalagin ameliorated endotoxemic acute kidney injury in rats by counteracting inflammation, oxidative/nitrative stress and apoptosis.Jul 26, 2016

Pubmed Data : Toxicol Mech Methods. 2016 Jul 27:1-6. Epub 2016 Aug 27. PMID: 27464552
Article Published Date : Jul 26, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Kidney Damage: Chemically-Induced, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective
[+]

Punicalagin ameliorates endothelial dysfunction.Mar 12, 2019

Pubmed Data : Free Radic Biol Med. 2019 Mar 13. Epub 2019 Mar 13. PMID: 30878647
Article Published Date : Mar 12, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cardiovascular Diseases, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Punicalagin ameliorates lipopolysaccharide-induced acute respiratory distress syndrome in mice.Mar 31, 2015

Pubmed Data : Inflammation. 2015 Apr ;38(2):493-9. PMID: 25005005
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Acute Respiratory Distress Syndrome, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:467465. Epub 2014 May 14. PMID: 24949451
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin, Tannic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Antimutagenic Agents, Antioxidants
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
[+]

Punicalagin can protect against acrylamide-induced toxicity through antioxidant and anti-apoptotic properties.Jun 26, 2020

Pubmed Data : Phytother Res. 2020 Jun 27. Epub 2020 Jun 27. PMID: 32592417
Article Published Date : Jun 26, 2020
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Acrylamide-induced toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Neuroprotective Agents
Problem Substances : Acrylamide
[+]

Punicalagin has a beneficial effect against S. typhimurium infection in mice.Jun 17, 2015

Pubmed Data : Food Funct. 2015 Jun 18. Epub 2015 Jun 18. PMID: 26084785
Article Published Date : Jun 17, 2015
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Infective Agents, Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin induces Nrf2 translocation and HO-1 expression, protecting rat intestinal epithelial cells from oxidative stress.Apr 06, 2016

Pubmed Data : Int J Hyperthermia. 2016 Apr 7:1-9. Epub 2016 Apr 7. PMID: 27055862
Article Published Date : Apr 06, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Gastroprotective, Heme oxygenase-1 inducer, Nrf2 activation
Additional Keywords : Dose Response
[+]

Punicalagin inhibits lipopolysaccharide induced memory impairment via anti-inflammatory and anti-amylogenic mechanisms.Jan 25, 2017

Pubmed Data : Neuropharmacology. 2017 Jan 26 ;117:21-32. Epub 2017 Jan 26. PMID: 28132781
Article Published Date : Jan 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin might play an important role in male infertility treatment, especially in the type of infertility induced by oxidative stress.Aug 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Aug 11 ;17(8). Epub 2016 Aug 11. PMID: 27529221
Article Published Date : Aug 10, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Infertility: Male, Oxidative Stress
Problem Substances : Lead
[+]

Punicalagin pre-treatment could protect against ischemia/reperfusion induced oxidative stress and myocardial injury via activation of AMPK.Jan 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Chin Med. 2017 Jan 13:1-14. Epub 2017 Jan 13. PMID: 28081629
Article Published Date : Jan 12, 2017
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Punicalagin prevents hypoxic pulmonary hypertension in rats. Dec 31, 2015

Pubmed Data : Am J Chin Med. 2016 ;44(4):785-801. Epub 2016 Aug 24. PMID: 27222062
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Endothelial Dysfunction, Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Antioxidants
[+]

Punicalagin protected from methionine-induced hyperhomocysteinemia and brain damage.Mar 22, 2018

Pubmed Data : Biomed Pharmacother. 2018 Mar 23 ;102:472-480. Epub 2018 Mar 23. PMID: 29579708
Article Published Date : Mar 22, 2018
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Hypermethioninemia
Pharmacological Actions : Neuroprotective Agents
[+]

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID: 27310207
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Hepatoprotective
[+]

Punicalagin protects diabetic nephropathy.May 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 May 22 ;12(5). Epub 2020 May 22. PMID: 32456088
Article Published Date : May 21, 2020
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Punicalagin significantly reduced glucose levels in high fat diet mice and improved HDL anti-inflammatory properties.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:2673076. Epub 2018 Jul 31. PMID: 30151068
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents
[+]

Punicalagin supplements could mitigate the teratogenic effects of hyperglycemia in the developing embryo.Nov 12, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2015 Nov 13 ;467(2):179-84. Epub 2015 Oct 13. PMID: 26453010
Article Published Date : Nov 12, 2015
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Diabetic Complications, Hyperglycemia, Lipid Peroxidation, Neural Tube Defects, Oxidative Stress
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
Additional Keywords : Risk Reduction
[+]

Supplementation with a punicalagin-rich pomegranate extract may protect skeletal muscle against an acute inflammation.Nov 01, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 2. Epub 2016 Aug 2. PMID: 27804206
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Punicalagin, Urolithin A
Diseases : Cachexia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2018 Jul ;22(4):409-417. Epub 2018 Jun 25. PMID: 29962855
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

A review of phenolic compounds as beneficial phytochemicals in pomegranate.Sep 29, 2018

Pubmed Data : Food Chem. 2018 Sep 30 ;261:75-86. Epub 2018 Apr 13. PMID: 29739608
Article Published Date : Sep 29, 2018
Study Type : Review
Additional Links
Substances : Anthocyanins, Cinnamic acid, Cyanidin, Delphinidin, Ellagic Acid, Flavonoids, Gallic Acid, Pomegranate, Punicalagin
[+]

Advances on natural polyphenols as anticancer agents for skin cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2020 01 ;151:104584. Epub 2019 Dec 3. PMID: 31809853
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Punicalagin, Quercetin, Resveratrol, Theaflavins
Diseases : Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Chemopreventive
[+]

Antifungal activity of punicalagin-nystatin combinations against Candida albicans.Jun 23, 2020

Pubmed Data : Oral Dis. 2020 Jun 24. Epub 2020 Jun 24. PMID: 32583467
Article Published Date : Jun 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Candida Albicans
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.Jan 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jan 14 ;17(1):47. Epub 2017 Jan 14. PMID: 28088220
Article Published Date : Jan 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Gallic Acid, Pomegranate, Punicalagin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
[+]

Hydrolyzable tannins inhibit hepatitis B cccDNA production.Sep 30, 2016

Pubmed Data : Antiviral Res. 2016 Oct ;134:97-107. Epub 2016 Aug 31. PMID: 27591143
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Hepatitis B
Pharmacological Actions : Antiviral Agents
Additional Keywords : Tannins
[+]

Peels and flesh extract of Sour-YRP significantly inhibited the proliferation of HepG2 and Hela cancer cells lines.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Springerplus. 2016 ;5(1):914. Epub 2016 Jun 29. PMID: 27386358
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Pomegranate Peel, Punicalagin
Diseases : Cervical Cancer, Liver Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Antiproliferative, Cervical Cancer, liver cancer, Plant Extracts, pomegranate, Pomegranate Peel, punicalagin
[+]

Pomegranate may offer an attractive dietary strategy for the prevention and treatment of AGE-related diseases such as type-2 diabetes and Alzheimer's disease.Oct 31, 2014

Pubmed Data : Food Funct. 2014 Nov ;5(11):2996-3004. PMID: 25233108
Article Published Date : Oct 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin, Tannic Acid
Diseases : Advanced Glycation End products (AGE), Alzheimer's Disease, Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Pomegranate peel extract and punicalagin may be useful in alleviating inflammatory reactions due to particulate matter.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:6836080. Epub 2016 May 10. PMID: 27247608
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Pomegranates have potential as a novel approach in ameliorating the inflammation and pain associated with a range of skin conditions.Nov 16, 2016

Pubmed Data : Eur J Pharm Biopharm. 2016 Nov 17. Epub 2016 Nov 17. PMID: 27867111
Article Published Date : Nov 16, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Protection of the myocardium against ischemia/reperfusion injury by punicalagin.May 31, 2019

Pubmed Data : Chem Biol Interact. 2019 Jun 1 ;306:152-162. Epub 2019 May 4. PMID: 31063767
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effects of punicalagin on osteoporosis by inhibiting osteoclastogenesis and inflammation.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:696. Epub 2020 May 15. PMID: 32477149
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective
[+]

Pulsed ultrasound-assisted extraction had a high efficiency for extraction of phenolics from pomegranate peel.Aug 31, 2016

Pubmed Data : Food Chem. 2016 Sep 1 ;206:156-66. Epub 2016 Mar 10. PMID: 27041311
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Additional Keywords : Ultrasound
[+]

Punicalagin ameliorates lupus nephritis via inhibition of PAR2.Jul 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Jul 14 ;21(14). Epub 2020 Jul 14. PMID: 32674502
Article Published Date : Jul 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Lupus Nephritis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin and zinc has potential for the topical treatment of HSV infections.Aug 07, 2016

Pubmed Data : Eur J Pharm Sci. 2016 Aug 8 ;96:99-106. Epub 2016 Aug 8. PMID: 27516148
Article Published Date : Aug 07, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin, Zinc
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Punicalagin could effectively attenuate FFA-induced lipotoxicity by activating Keap1-Nrf2 cytoprotective signaling pathway.Apr 30, 2016

Pubmed Data : Mol Nutr Food Res. 2016 May ;60(5):1139-49. Epub 2016 Apr 14. PMID: 26989875
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Nrf2 activation
Problem Substances : Retinyl palmitate
[+]

Punicalagin damages the membrane of Salmonella typhimurium. Jul 13, 2020

Pubmed Data : J Food Prot. 2020 Jul 14. Epub 2020 Jul 14. PMID: 32663262
Article Published Date : Jul 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Salmonella Infections
Pharmacological Actions : Antimicrobial
[+]

Punicalagin exerts anti-proliferative activity in prostate cancer cells via induction of apoptosis and anti-angiogenic effects.Jul 10, 2017

Pubmed Data : Chem Biol Interact. 2017 Jul 11. Epub 2017 Jul 11. PMID: 28709945
Article Published Date : Jul 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Prostate Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
[+]

Punicalagin exhibited neuroprotective effects on the 6-OHDA-treated SH-SY5Y cells.Aug 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Aug 25 ;24:5905-5913. Epub 2018 Aug 25. PMID: 30143600
Article Published Date : Aug 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Punicalagin has a high capacity to induce DNA repair.Oct 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Nov 1 ;310:1-8. Epub 2016 Aug 18. PMID: 27546523
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cancers: All, DNA damage
Pharmacological Actions : Anti-Angiogenic, Chemopreventive, DNA Repair Up-regulation
[+]

Punicalagin has antimicrobial and antibiofilm activities against S. aureus.Jan 26, 2017

Pubmed Data : Foodborne Pathog Dis. 2017 Jan 27. Epub 2017 Jan 27. PMID: 28128637
Article Published Date : Jan 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Biofilm
[+]

Punicalagin has potential as an oral agent to control obesity-mediated diseases.Aug 23, 2019

Pubmed Data : Mol Nutr Food Res. 2019 Aug 24:e1900574. Epub 2019 Aug 24. PMID: 31444955
Article Published Date : Aug 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Anti-Obesity Agents
[+]

Punicalagin in combination with zinc may promote certain anti-inflammatory and fibroblast responses to aid oral healing.Aug 24, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Aug 25 ;10(9). Epub 2020 Aug 25. PMID: 32854243
Article Published Date : Aug 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Punicalagin, Zinc
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells.Apr 16, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr 17 ;103:490-498. Epub 2018 Apr 17. PMID: 29677534
Article Published Date : Apr 16, 2018
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Thyroid Cancer
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor
[+]

Punicalagin inhibits Salmonella virulence factors and has anti-quorum-sensing potential.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Environ Microbiol. 2014 Oct ;80(19):6204-11. Epub 2014 Aug 1. PMID: 25085489
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition
[+]

Punicalagin inhibits the viability, migration, invasion, and EMT by regulating GOLPH3 in breast cancer cells. Mar 31, 2020

Pubmed Data : J Recept Signal Transduct Res. 2020 Apr ;40(2):173-180. Epub 2020 Feb 6. PMID: 32024401
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Punicalagin is a neuraminidase inhibitor of influenza viruses.Aug 21, 2020

Pubmed Data : J Med Virol. 2020 Aug 22. Epub 2020 Aug 22. PMID: 32827314
Article Published Date : Aug 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Punicalagin is a promising therapeutic agent for oxidative stress associated diseases.Jan 08, 2017

Pubmed Data : Neurotox Res. 2017 Jan 9. Epub 2017 Jan 9. PMID: 28070799
Article Published Date : Jan 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Punicalagin may have cancer-chemopreventive as well as cancer-chemotherapeutic effects against human ovarian cancer.Aug 18, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Gynecol Cancer. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27540692
Article Published Date : Aug 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Chemopreventive, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Punicalagin may protect against carbon tetrachloride-induced liver injury through the upregulation of antioxidative activities and autophagy.Nov 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31718395
Article Published Date : Nov 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, Nrf2 activation
[+]

Punicalagin might be used therapeutically in pregnancies at risk for placental dysfunction. Jul 31, 2016

Pubmed Data : Placenta. 2016 Aug ;44:80-2. Epub 2016 Aug 13. PMID: 27452441
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Placenta Diseases, Pregnancy Complications
[+]

Punicalagin played an important role in the attenuation of LPS-induced inflammatory responses in RAW264.7 macrophages.Nov 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 15 ;11(11). Epub 2019 Nov 15. PMID: 31731808
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin promotes the apoptosis in human cervical cancer.Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Apr ;27(4):1100-1106. Epub 2020 Mar 4. PMID: 32256171
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through activation of Nrf2/HO-1 signaling.Apr 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31015369
Article Published Date : Apr 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Punicalagin reduces expression of virulence-related exoproteins by Staphylococcus aureus.Oct 31, 2016

Pubmed Data : FEMS Microbiol Lett. 2016 Nov ;363(22). Epub 2016 Nov 9. PMID: 27974390
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
[+]

Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells.Apr 08, 2017

Pubmed Data : Nutr Neurosci. 2017 Apr 9:1-8. Epub 2017 Apr 9. PMID: 28393656
Article Published Date : Apr 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Hydrogen Peroxide Induced Toxicity, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Punicalagin regulates apoptosis-autophagy switch via modulation of annexin A1 in colorectal cancer.Aug 12, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Aug 13 ;12(8). Epub 2020 Aug 13. PMID: 32823596
Article Published Date : Aug 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Punicalagin showed 100% anti-HSV-2 activity at 31.25 μg/ml.Apr 30, 2018

Pubmed Data : Microb Pathog. 2018 May ;118:301-309. Epub 2018 Mar 28. PMID: 29604421
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin
Diseases : Herpes Simplex Virus Type 2
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Punicalagin stimulates LDL influx to macrophages, thus reducing circulating cholesterol levels.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:7124251. Epub 2016 Aug 19. PMID: 27516832
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : High Cholesterol
Pharmacological Actions : Anticholesteremic Agents
[+]

Punicalagin suppresses methicillin resistance of Staphylococcus aureus to oxacillin.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2018 Aug ;137(4):317-323. Epub 2017 Dec 27. PMID: 30150143
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Resveratrol and punicalagin have a possible preventive role in Alzheimer and in other neurodegenerative diseases.Dec 31, 2014

Pubmed Data : J Prev Alzheimers Dis. 2015 ;2(1):33-37. PMID: 29234773
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin, Resveratrol
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

These observations confirmed the suppressive effect of punicalagin against osteosarcoma malignancies.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Sep ;22(3):2386-2394. Epub 2020 Jul 6. PMID: 32705250
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Osteosarcoma
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor
[+]

These polyphenols may be used to prevent S. aureus infection and staphylococcal food poisoning.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(6):e0157082. Epub 2016 Aug 7. PMID: 27272505
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Polyphenols, Punicalagin
Diseases : Staphylococcal Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

These results suggest that punicalagin inhibits neuroinflammation in lipopolysaccharide-activated microglia.Aug 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Sep ;58(9):1843-51. Epub 2014 Jul 28. PMID: 25066095
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggested that punicalagin may have chemopreventive and chemotherapeutic effects against cervical cancer.Jun 05, 2017

Pubmed Data : Mol Med Rep. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28586031
Article Published Date : Jun 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemopreventive, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Copyright: atoss / 123RF Stock Photo

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