Punicalagin

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74 Diseases Researched for Punicalagin
NameACCKFocus
Hyperglycemia212Locked
Inflammation812Locked
Atherosclerosis211Locked
Lipopolysaccharide-Induced Toxicity610Locked
Oxidative Stress610Locked
Air Pollution Linked Toxicity26Locked
High Fat Diet36Locked
Eye Damage15Locked
Photooxidative Stress15Locked
Ultraviolet Radiation Induced Damage15Locked
Diabetes Mellitus: Type 224Locked
Endothelial Dysfunction24Locked
Infertility: Male24Locked
Salmonella Infections34Locked
Brain Inflammation 23Locked
Cervical Cancer33Locked
DNA damage23Locked
Myocardial Ischemia23Locked
Staphylococcus aureus infection33Locked
Acrylamide-induced toxicity12Locked
Acute Respiratory Distress Syndrome12Locked
Alzheimer's Disease22Locked
Benzo[a]pyrene-induced Toxicity 12Locked
Cachexia12Locked
Candida Albicans22Locked
Cardiovascular Diseases12Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide12Locked
Chemotherapy-Induced Toxicity: Doxorubicin22Locked
Diabetic Complications12Locked
Diabetic Nephropathy12Locked
Hyperlipidemia12Locked
Hypermethioninemia12Locked
Hypertension12Locked
Hypertension: Pulmonary12Locked
Hypoxia12Locked
Kidney Damage: Chemically-Induced12Locked
Lipid Peroxidation12Locked
Liver Damage12Locked
Memory Disorders12Locked
Neural Tube Defects12Locked
Osteosarcoma22Locked
Advanced Glycation End products (AGE)11Locked
Brain: Microglial Activation11Locked
Breast Cancer11Locked
Cancers: All11Locked
Chemically-Induced Liver Damage11Locked
Colorectal Cancer11Locked
Diabetes Mellitus: Type 2: Prevention11Locked
Hepatitis B 11Locked
Herpes Simplex Virus Type 111Locked
Herpes Simplex Virus Type 211Locked
High Cholesterol11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Influenza11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Lupus Nephritis11Locked
Methicillin-resistant Staphylococcus aureus11Locked
Neurodegenerative Diseases11Locked
Nonalcoholic fatty liver disease (NAFLD)11Locked
Obesity11Locked
Osteoarthritis11Locked
Osteoporosis11Locked
Ovarian Cancer11Locked
Parkinson's Disease11Locked
Placenta Diseases11Locked
Pregnancy Complications11Locked
Prostate Cancer11Locked
Skin Cancer11Locked
Spondylitis: Ankylosing11Locked
Staphylococcal Infections11Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)11Locked
Thyroid Cancer11Locked
Wound Healing11Locked
54 Pharmacological Actions Researched for Punicalagin
NameACCKFocus
Anti-Inflammatory Agents2538Locked
Antioxidants2235Locked
Hypoglycemic Agents416Locked
Nrf2 activation915Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor815Locked
Interleukin-6 Downregulation814Locked
Anti-Apoptotic613Locked
NF-kappaB Inhibitor912Locked
Anti-atherogenic110Locked
Antiproliferative 99Locked
Interleukin-1 beta downregulation39Locked
Hepatoprotective58Locked
Heme oxygenase-1 up-regulation37Locked
Interleukin-8 downregulation37Locked
Neuroprotective Agents57Locked
Apoptotic66Locked
Cyclooxygenase 2 Inhibitors46Locked
Anti-metastatic44Locked
Antimicrobial44Locked
Antiviral Agents44Locked
Cardioprotective34Locked
Chemopreventive44Locked
Renoprotective24Locked
Anti-Bacterial Agents33Locked
Interferon Gamma Reducer23Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor33Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor33Locked
Anti-Infective Agents12Locked
Antihypertensive Agents12Locked
Antimutagenic Agents12Locked
Catalase Up-Regulation12Locked
Chemoprotective Agents22Locked
Fertility Agents12Locked
Gastrointestinal Agents12Locked
Gastroprotective12Locked
Heme oxygenase-1 inducer12Locked
Hypolipidemic12Locked
Interleukin-10 downregulation12Locked
Nitric Oxide Inhibitor22Locked
Osteoprotective 22Locked
Superoxide Dismutase Up-regulation12Locked
Angiogenesis Inhibitors11Locked
Anti-Angiogenic11Locked
Anticholesteremic Agents11Locked
Antifungal Agents11Locked
Autophagy Up-regulation11Locked
Cell cycle arrest11Locked
Chemotherapeutic11Locked
Chondroprotective11Locked
Cytoprotective11Locked
DNA Repair Up-regulation11Locked
Immunomodulatory: Th17 downregulation11Locked
Prostaglandin PGE2 downregulation11Locked
Quorum Sensing Inhibition11Locked

View the Evidence:
91 Abstracts with Punicalagin Research

[+]

Pomegranate juice confers a lower glycemic response on a high-glycemic index food.Oct 10, 2017

Pubmed Data : Am J Clin Nutr. 2017 Oct 11. Epub 2017 Oct 11. PMID: 29021286
Article Published Date : Oct 10, 2017
Study Type : Human Study
Additional Links
Substances : Pomegranate, Punicalagin
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

Punicalagin might be one of natural therapeutic compounds for relieving rheumatoid arthritis progression.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2021 ;14:1901-1913. Epub 2021 May 12. PMID: 34012288
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Punicalagin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers.Mar 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Mar 16 ;11(3). Epub 2019 Mar 16. PMID: 30884808
Article Published Date : Mar 15, 2019
Study Type : Human Study
Additional Links
Substances : Hydroxytyrosol, Punicalagin
Diseases : Atherosclerosis
Pharmacological Actions : Anti-atherogenic
[+]

Punicalagin and EGCG can rescue keratinocyte viability and attenuate the inflammatory responses of cells due to airborne particles.Mar 21, 2018

Pubmed Data : Skin Pharmacol Physiol. 2018 Mar 22 ;31(3):134-143. Epub 2018 Mar 22. PMID: 29566388
Article Published Date : Mar 21, 2018
Study Type : Human In Vitro
Additional Links
Substances : EGCG (Epigallocatechin gallate), Punicalagin
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jun 2 ;9(6). Epub 2020 Jun 2. PMID: 32498245
Article Published Date : Jun 01, 2020
Study Type : Human In Vitro
Additional Links
Substances : Punicalagin
Diseases : Eye Damage, Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

A new possible mechanism by which punicalagin protects against liver injury induced by type 2 diabetes mellitus.Nov 06, 2019

Pubmed Data : J Agric Food Chem. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31698901
Article Published Date : Nov 06, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Diabetes Mellitus: Type 2, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

A new way for punicalagin to alleviate insulin resistance: regulating gut microbiota and autophagy Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2021 ;65. Epub 2021 Jul 1. PMID: 34262422
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Insulin Resistance
Pharmacological Actions : Autophagy Up-regulation, Gastrointestinal Agents, Hepatoprotective, Hypolipidemic, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

By promoting fertility and eliminating oxidative stress and inflammation, Punicalagin may be a useful nutrient for the treatment of infertility.Jan 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian J Androl. 2016 Jan 12. Epub 2016 Jan 12. PMID: 26763544
Article Published Date : Jan 11, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Infertility: Male, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Fertility Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Effect of punicalagin on multiple targets in streptozotocin/high-fat diet-induced diabetic mice.Nov 18, 2020

Pubmed Data : Food Funct. 2020 Nov 19. Epub 2020 Nov 19. PMID: 33210684
Article Published Date : Nov 18, 2020
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Diabetes Mellitus: Type 2, High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, NF-kappaB Inhibitor
[+]

Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses in rats fed a high-fat diet.Nov 12, 2019

Pubmed Data : Food Funct. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31720661
Article Published Date : Nov 12, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Pomegranate Polyphenols, Punicalagin, Urolithin A
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Punicalagin ameliorated endotoxemic acute kidney injury in rats by counteracting inflammation, oxidative/nitrative stress and apoptosis.Jul 26, 2016

Pubmed Data : Toxicol Mech Methods. 2016 Jul 27:1-6. Epub 2016 Aug 27. PMID: 27464552
Article Published Date : Jul 26, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Kidney Damage: Chemically-Induced, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective
[+]

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway.Jun 09, 2021

Pubmed Data : Sci China Life Sci. 2021 Jun 10. Epub 2021 Jun 10. PMID: 34125371
Article Published Date : Jun 09, 2021
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Punicalagin ameliorates endothelial dysfunction.Mar 12, 2019

Pubmed Data : Free Radic Biol Med. 2019 Mar 13. Epub 2019 Mar 13. PMID: 30878647
Article Published Date : Mar 12, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cardiovascular Diseases, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Punicalagin ameliorates lipopolysaccharide-induced acute respiratory distress syndrome in mice.Mar 31, 2015

Pubmed Data : Inflammation. 2015 Apr ;38(2):493-9. PMID: 25005005
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Acute Respiratory Distress Syndrome, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin and ellagic acid demonstrate antimutagenic activity and inhibition of benzo[a]pyrene induced DNA adducts.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:467465. Epub 2014 May 14. PMID: 24949451
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin, Tannic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Antimutagenic Agents, Antioxidants
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
[+]

Punicalagin can protect against acrylamide-induced toxicity through antioxidant and anti-apoptotic properties.Jun 26, 2020

Pubmed Data : Phytother Res. 2020 Jun 27. Epub 2020 Jun 27. PMID: 32592417
Article Published Date : Jun 26, 2020
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Acrylamide-induced toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Neuroprotective Agents
Problem Substances : Acrylamide
[+]

Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats.Mar 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Integr Neurosci. 2021 Mar 30 ;20(1):87-93. PMID: 33834694
Article Published Date : Mar 29, 2021
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Memory Disorders: Sleep Deprivation Induced
Pharmacological Actions : Neuroprotective Agents
[+]

Punicalagin has a beneficial effect against S. typhimurium infection in mice.Jun 17, 2015

Pubmed Data : Food Funct. 2015 Jun 18. Epub 2015 Jun 18. PMID: 26084785
Article Published Date : Jun 17, 2015
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Infective Agents, Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin improves hepatic lipid metabolism via modulation of oxidative stress and mitochondrial biogenesis in hyperlipidemic mice.Sep 24, 2020

Pubmed Data : Food Funct. 2020 Sep 25. Epub 2020 Sep 25. PMID: 32975274
Article Published Date : Sep 24, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

Punicalagin induces Nrf2 translocation and HO-1 expression, protecting rat intestinal epithelial cells from oxidative stress.Apr 06, 2016

Pubmed Data : Int J Hyperthermia. 2016 Apr 7:1-9. Epub 2016 Apr 7. PMID: 27055862
Article Published Date : Apr 06, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Gastroprotective, Heme oxygenase-1 inducer, Nrf2 activation
Additional Keywords : Dose Response
[+]

Punicalagin inhibits lipopolysaccharide induced memory impairment via anti-inflammatory and anti-amylogenic mechanisms.Jan 25, 2017

Pubmed Data : Neuropharmacology. 2017 Jan 26 ;117:21-32. Epub 2017 Jan 26. PMID: 28132781
Article Published Date : Jan 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin might play an important role in male infertility treatment, especially in the type of infertility induced by oxidative stress.Aug 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Aug 11 ;17(8). Epub 2016 Aug 11. PMID: 27529221
Article Published Date : Aug 10, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Infertility: Male, Oxidative Stress
Problem Substances : Lead
[+]

Punicalagin pre-treatment could protect against ischemia/reperfusion induced oxidative stress and myocardial injury via activation of AMPK.Jan 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Chin Med. 2017 Jan 13:1-14. Epub 2017 Jan 13. PMID: 28081629
Article Published Date : Jan 12, 2017
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Punicalagin prevents hypoxic pulmonary hypertension in rats. Dec 31, 2015

Pubmed Data : Am J Chin Med. 2016 ;44(4):785-801. Epub 2016 Aug 24. PMID: 27222062
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Endothelial Dysfunction, Hypertension: Pulmonary, Hypoxia
Pharmacological Actions : Antioxidants
[+]

Punicalagin protected from methionine-induced hyperhomocysteinemia and brain damage.Mar 22, 2018

Pubmed Data : Biomed Pharmacother. 2018 Mar 23 ;102:472-480. Epub 2018 Mar 23. PMID: 29579708
Article Published Date : Mar 22, 2018
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Hypermethioninemia
Pharmacological Actions : Neuroprotective Agents
[+]

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID: 27310207
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Hepatoprotective
[+]

Punicalagin protects diabetic nephropathy.May 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 May 22 ;12(5). Epub 2020 May 22. PMID: 32456088
Article Published Date : May 21, 2020
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Punicalagin significantly reduced glucose levels in high fat diet mice and improved HDL anti-inflammatory properties.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:2673076. Epub 2018 Jul 31. PMID: 30151068
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents
[+]

Punicalagin supplements could mitigate the teratogenic effects of hyperglycemia in the developing embryo.Nov 12, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2015 Nov 13 ;467(2):179-84. Epub 2015 Oct 13. PMID: 26453010
Article Published Date : Nov 12, 2015
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Diabetic Complications, Hyperglycemia, Lipid Peroxidation, Neural Tube Defects, Oxidative Stress
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
Additional Keywords : Risk Reduction
[+]

Supplementation with a punicalagin-rich pomegranate extract may protect skeletal muscle against an acute inflammation.Nov 01, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 2. Epub 2016 Aug 2. PMID: 27804206
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Punicalagin, Urolithin A
Diseases : Cachexia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2018 Jul ;22(4):409-417. Epub 2018 Jun 25. PMID: 29962855
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
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A review of phenolic compounds as beneficial phytochemicals in pomegranate.Sep 29, 2018

Pubmed Data : Food Chem. 2018 Sep 30 ;261:75-86. Epub 2018 Apr 13. PMID: 29739608
Article Published Date : Sep 29, 2018
Study Type : Review
Additional Links
Substances : Anthocyanins, Cinnamic acid, Cyanidin, Delphinidin, Ellagic Acid, Flavonoids, Gallic Acid, Pomegranate, Punicalagin
[+]

Advances on natural polyphenols as anticancer agents for skin cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2020 01 ;151:104584. Epub 2019 Dec 3. PMID: 31809853
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Punicalagin, Quercetin, Resveratrol, Theaflavins
Diseases : Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Chemopreventive
[+]

Antifungal activity of punicalagin-nystatin combinations against Candida albicans.Jun 23, 2020

Pubmed Data : Oral Dis. 2020 Jun 24. Epub 2020 Jun 24. PMID: 32583467
Article Published Date : Jun 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Candida Albicans
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CL pro.Apr 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antiviral Res. 2021 Apr 17 ;190:105075. Epub 2021 Apr 17. PMID: 33872675
Article Published Date : Apr 16, 2021
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Effects of short-duration treatment of cartilage with punicalagin and genipin and the implications for treatment of osteoarthritis.Oct 25, 2020

Pubmed Data : J Biomed Mater Res B Appl Biomater. 2020 Oct 26. Epub 2020 Oct 26. PMID: 33103838
Article Published Date : Oct 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Genipin, Punicalagin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Osteoprotective
[+]

Ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.Jan 13, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jan 14 ;17(1):47. Epub 2017 Jan 14. PMID: 28088220
Article Published Date : Jan 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Gallic Acid, Pomegranate, Punicalagin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation
[+]

Hydrolyzable tannins inhibit hepatitis B cccDNA production.Sep 30, 2016

Pubmed Data : Antiviral Res. 2016 Oct ;134:97-107. Epub 2016 Aug 31. PMID: 27591143
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Hepatitis B
Pharmacological Actions : Antiviral Agents
Additional Keywords : Tannins
[+]

Identification of punicalagin as the bioactive compound behind the antimicrobial activity of pomegranate.Jul 31, 2021

Pubmed Data : Food Chem. 2021 Aug 1 ;352:129396. Epub 2021 Feb 23. PMID: 33652195
Article Published Date : Jul 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections
Pharmacological Actions : Antimicrobial
[+]

Natural compounds against doxorubicin-induced cardiotoxicity.Sep 27, 2020

Pubmed Data : Phytother Res. 2020 Sep 28. Epub 2020 Sep 28. PMID: 32985744
Article Published Date : Sep 27, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid, Apigenin, Asiatic Acid, Ferulic acid, Genistein, Ginsenosides, Indole-3-Carbinol, Naringenin , P-Coumaric Acid, Punicalagin, Quercetin, Reishi Mushroom, Sulforaphane, Tanshinone IIA
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Peels and flesh extract of Sour-YRP significantly inhibited the proliferation of HepG2 and Hela cancer cells lines.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Springerplus. 2016 ;5(1):914. Epub 2016 Jun 29. PMID: 27386358
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Pomegranate Peel, Punicalagin
Diseases : Cervical Cancer, Liver Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Antiproliferative, Cervical Cancer, liver cancer, Plant Extracts, pomegranate, Pomegranate Peel, punicalagin
[+]

Pomegranate may offer an attractive dietary strategy for the prevention and treatment of AGE-related diseases such as type-2 diabetes and Alzheimer's disease.Oct 31, 2014

Pubmed Data : Food Funct. 2014 Nov ;5(11):2996-3004. PMID: 25233108
Article Published Date : Oct 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin, Tannic Acid
Diseases : Advanced Glycation End products (AGE), Alzheimer's Disease, Diabetes Mellitus: Type 2: Prevention
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Pomegranate peel extract and punicalagin may be useful in alleviating inflammatory reactions due to particulate matter.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:6836080. Epub 2016 May 10. PMID: 27247608
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Pomegranates have potential as a novel approach in ameliorating the inflammation and pain associated with a range of skin conditions.Nov 16, 2016

Pubmed Data : Eur J Pharm Biopharm. 2016 Nov 17. Epub 2016 Nov 17. PMID: 27867111
Article Published Date : Nov 16, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Protection of the myocardium against ischemia/reperfusion injury by punicalagin.May 31, 2019

Pubmed Data : Chem Biol Interact. 2019 Jun 1 ;306:152-162. Epub 2019 May 4. PMID: 31063767
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effects of punicalagin on osteoporosis by inhibiting osteoclastogenesis and inflammation.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:696. Epub 2020 May 15. PMID: 32477149
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective
[+]

Pulsed ultrasound-assisted extraction had a high efficiency for extraction of phenolics from pomegranate peel.Aug 31, 2016

Pubmed Data : Food Chem. 2016 Sep 1 ;206:156-66. Epub 2016 Mar 10. PMID: 27041311
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel, Punicalagin
Additional Keywords : Ultrasound
[+]

Punicalagin ameliorates lupus nephritis via inhibition of PAR2.Jul 13, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Jul 14 ;21(14). Epub 2020 Jul 14. PMID: 32674502
Article Published Date : Jul 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Lupus Nephritis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin and zinc (II) ions inhibit the activity of SARS-CoV-2 3CL-protease in vitro.Dec 31, 2020

Pubmed Data : Eur Rev Med Pharmacol Sci. 2021 05 ;25(10):3908-3913. PMID: 34109605
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin, Zinc
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Punicalagin and zinc has potential for the topical treatment of HSV infections.Aug 07, 2016

Pubmed Data : Eur J Pharm Sci. 2016 Aug 8 ;96:99-106. Epub 2016 Aug 8. PMID: 27516148
Article Published Date : Aug 07, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin, Zinc
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents
[+]

Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis.Jun 22, 2021

Pubmed Data : Bone. 2021 Jun 23 ;152:116070. Epub 2021 Jun 23. PMID: 34171516
Article Published Date : Jun 22, 2021
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Osteoprotective
[+]

Punicalagin could effectively attenuate FFA-induced lipotoxicity by activating Keap1-Nrf2 cytoprotective signaling pathway.Apr 30, 2016

Pubmed Data : Mol Nutr Food Res. 2016 May ;60(5):1139-49. Epub 2016 Apr 14. PMID: 26989875
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Nrf2 activation
Problem Substances : Retinyl palmitate
[+]

Punicalagin damages the membrane of Salmonella typhimurium. Jul 13, 2020

Pubmed Data : J Food Prot. 2020 Jul 14. Epub 2020 Jul 14. PMID: 32663262
Article Published Date : Jul 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Salmonella Infections
Pharmacological Actions : Antimicrobial
[+]

Punicalagin exerts anti-proliferative activity in prostate cancer cells via induction of apoptosis and anti-angiogenic effects.Jul 10, 2017

Pubmed Data : Chem Biol Interact. 2017 Jul 11. Epub 2017 Jul 11. PMID: 28709945
Article Published Date : Jul 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Prostate Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
[+]

Punicalagin exhibited neuroprotective effects on the 6-OHDA-treated SH-SY5Y cells.Aug 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Aug 25 ;24:5905-5913. Epub 2018 Aug 25. PMID: 30143600
Article Published Date : Aug 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Punicalagin has a high capacity to induce DNA repair.Oct 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Nov 1 ;310:1-8. Epub 2016 Aug 18. PMID: 27546523
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cancers: All, DNA damage
Pharmacological Actions : Anti-Angiogenic, Chemopreventive, DNA Repair Up-regulation
[+]

Punicalagin has antimicrobial and antibiofilm activities against S. aureus.Jan 26, 2017

Pubmed Data : Foodborne Pathog Dis. 2017 Jan 27. Epub 2017 Jan 27. PMID: 28128637
Article Published Date : Jan 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Biofilm
[+]

Punicalagin has potential as an oral agent to control obesity-mediated diseases.Aug 23, 2019

Pubmed Data : Mol Nutr Food Res. 2019 Aug 24:e1900574. Epub 2019 Aug 24. PMID: 31444955
Article Published Date : Aug 23, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Anti-Obesity Agents
[+]

Punicalagin in cancer prevention-Via signaling pathways targeting.Aug 08, 2021

Pubmed Data : Nutrients. 2021 Aug 9 ;13(8). Epub 2021 Aug 9. PMID: 34444893
Article Published Date : Aug 08, 2021
Study Type : Review
Additional Links
Substances : Punicalagin
Diseases : Bone Cancer, Breast Cancer, Cervical Cancer, Colorectal Cancer, Lung Cancer, Ovarian Cancer, Thyroid Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Plant Extracts
[+]

Punicalagin in combination with zinc may promote certain anti-inflammatory and fibroblast responses to aid oral healing.Aug 24, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2020 Aug 25 ;10(9). Epub 2020 Aug 25. PMID: 32854243
Article Published Date : Aug 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Punicalagin, Zinc
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Punicalagin induces apoptosis in A549 cell line through mitochondria-mediated pathway.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gen Physiol Biophys. 2020 Nov ;39(6):557-567. PMID: 33226364
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Punicalagin induces ROS-mediated apoptotic cell death through inhibiting STAT3 translocation in lung cancer A549 cells.Mar 14, 2021

Pubmed Data : J Biochem Mol Toxicol. 2021 Mar 15:e22771. Epub 2021 Mar 15. PMID: 33720461
Article Published Date : Mar 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, STAT3 Inhibitor
[+]

Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells.Apr 16, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr 17 ;103:490-498. Epub 2018 Apr 17. PMID: 29677534
Article Published Date : Apr 16, 2018
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Thyroid Cancer
Pharmacological Actions : Antiproliferative , NF-kappaB Inhibitor
[+]

Punicalagin inhibits Salmonella virulence factors and has anti-quorum-sensing potential.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Environ Microbiol. 2014 Oct ;80(19):6204-11. Epub 2014 Aug 1. PMID: 25085489
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Salmonella Infections
Pharmacological Actions : Anti-Bacterial Agents, Quorum Sensing Inhibition
[+]

Punicalagin inhibits the viability, migration, invasion, and EMT by regulating GOLPH3 in breast cancer cells. Mar 31, 2020

Pubmed Data : J Recept Signal Transduct Res. 2020 Apr ;40(2):173-180. Epub 2020 Feb 6. PMID: 32024401
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Punicalagin is a neuraminidase inhibitor of influenza viruses.Aug 21, 2020

Pubmed Data : J Med Virol. 2020 Aug 22. Epub 2020 Aug 22. PMID: 32827314
Article Published Date : Aug 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Punicalagin is a promising therapeutic agent for oxidative stress associated diseases.Jan 08, 2017

Pubmed Data : Neurotox Res. 2017 Jan 9. Epub 2017 Jan 9. PMID: 28070799
Article Published Date : Jan 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Punicalagin may have cancer-chemopreventive as well as cancer-chemotherapeutic effects against human ovarian cancer.Aug 18, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Gynecol Cancer. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27540692
Article Published Date : Aug 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Chemopreventive, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Punicalagin may protect against carbon tetrachloride-induced liver injury through the upregulation of antioxidative activities and autophagy.Nov 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Food. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31718395
Article Published Date : Nov 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, Nrf2 activation
[+]

Punicalagin might be used therapeutically in pregnancies at risk for placental dysfunction. Jul 31, 2016

Pubmed Data : Placenta. 2016 Aug ;44:80-2. Epub 2016 Aug 13. PMID: 27452441
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Placenta Diseases, Pregnancy Complications
[+]

Punicalagin played an important role in the attenuation of LPS-induced inflammatory responses in RAW264.7 macrophages.Nov 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 15 ;11(11). Epub 2019 Nov 15. PMID: 31731808
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Punicalagin promotes the apoptosis in human cervical cancer.Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Apr ;27(4):1100-1106. Epub 2020 Mar 4. PMID: 32256171
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Punicalagin protects against diabetic cardiomyopathy.Apr 27, 2021

Pubmed Data : Antioxid Redox Signal. 2021 Apr 28. Epub 2021 Apr 28. PMID: 33906428
Article Published Date : Apr 27, 2021
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cardiomyopathy, Diabetic Complications
Pharmacological Actions : Cardioprotective
[+]

Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through activation of Nrf2/HO-1 signaling.Apr 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31015369
Article Published Date : Apr 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Punicalagin reduces expression of virulence-related exoproteins by Staphylococcus aureus.Oct 31, 2016

Pubmed Data : FEMS Microbiol Lett. 2016 Nov ;363(22). Epub 2016 Nov 9. PMID: 27974390
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
[+]

Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells.Apr 08, 2017

Pubmed Data : Nutr Neurosci. 2017 Apr 9:1-8. Epub 2017 Apr 9. PMID: 28393656
Article Published Date : Apr 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Hydrogen Peroxide Induced Toxicity, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Punicalagin regulates apoptosis-autophagy switch via modulation of annexin A1 in colorectal cancer.Aug 12, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Aug 13 ;12(8). Epub 2020 Aug 13. PMID: 32823596
Article Published Date : Aug 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Punicalagin regulates key processes associated with atherosclerosis.Nov 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2020 Nov 8 ;13(11). Epub 2020 Nov 8. PMID: 33171640
Article Published Date : Nov 07, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Punicalagin showed 100% anti-HSV-2 activity at 31.25 μg/ml.Apr 30, 2018

Pubmed Data : Microb Pathog. 2018 May ;118:301-309. Epub 2018 Mar 28. PMID: 29604421
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Pomegranate, Punicalagin
Diseases : Herpes Simplex Virus Type 2
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Punicalagin stimulates LDL influx to macrophages, thus reducing circulating cholesterol levels.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:7124251. Epub 2016 Aug 19. PMID: 27516832
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : High Cholesterol
Pharmacological Actions : Anticholesteremic Agents
[+]

Punicalagin suppresses methicillin resistance of Staphylococcus aureus to oxacillin.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2018 Aug ;137(4):317-323. Epub 2017 Dec 27. PMID: 30150143
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Punicalagin suppresses osteosarcoma growth and metastasis by regulating NF-κB signaling.Aug 31, 2020

Pubmed Data : J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5):1699-1708. PMID: 33148374
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor
[+]

Punicalagin triggers ergosterol biosynthesis disruption and cell cycle arrest in Cryptococcus gattii and Candida albicans.Aug 26, 2020

Pubmed Data : Braz J Microbiol. 2020 Aug 27. Epub 2020 Aug 27. PMID: 32856241
Article Published Date : Aug 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
[+]

Resveratrol and punicalagin have a possible preventive role in Alzheimer and in other neurodegenerative diseases.Dec 31, 2014

Pubmed Data : J Prev Alzheimers Dis. 2015 ;2(1):33-37. PMID: 29234773
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin, Resveratrol
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

The observations suggest that punicalagin exerts a protective role in Ankylosing spondylitis.Dec 31, 2019

Pubmed Data : Biomed Res Int. 2020 ;2020:4918239. Epub 2020 Sep 23. PMID: 33029510
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Spondylitis: Ankylosing
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory: Th17 downregulation, NF-kappaB Inhibitor
[+]

These observations confirmed the suppressive effect of punicalagin against osteosarcoma malignancies.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Sep ;22(3):2386-2394. Epub 2020 Jul 6. PMID: 32705250
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Osteosarcoma
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor
[+]

These polyphenols may be used to prevent S. aureus infection and staphylococcal food poisoning.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(6):e0157082. Epub 2016 Aug 7. PMID: 27272505
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Polyphenols, Punicalagin
Diseases : Staphylococcal Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

These results suggest that punicalagin inhibits neuroinflammation in lipopolysaccharide-activated microglia.Aug 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Sep ;58(9):1843-51. Epub 2014 Jul 28. PMID: 25066095
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggested that punicalagin may have chemopreventive and chemotherapeutic effects against cervical cancer.Jun 05, 2017

Pubmed Data : Mol Med Rep. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28586031
Article Published Date : Jun 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemopreventive, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Copyright: atoss / 123RF Stock Photo

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4 Ways Pomegranate Extends Women's Lives
Written by GMI Reporter
Modern women at midlife have many options when it comes to dealing with those nasty menopausal symptoms like mood swings, depression, bone loss, and fluctuating estrogen levels. But their most surprising source of natural relief may come from an ancient food: the juicy pomegranate

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