Paeoniflorin

Name	AC	CK	Focus
Depression	1	1

Name	AC	CK	Focus
Antidepressive Agents	1	1
Gastrointestinal Agents	1	1

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Paeoniflorin may provide a new therapeutic approach to regulate P2X7R-mediated pathologic responses of primary Sjögren's syndrome.Aug 31, 2015

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Pubmed Data : Int Immunopharmacol. 2015 Sep ;28(1):115-20. Epub 2015 Jun 3. PMID: 26049028

Article Published Date : Aug 31, 2015

Study Type : Human In Vitro

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Substances : Paeoniflorin

Diseases : Sjogren's Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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Anticonvulsive effect of paeoniflorin on experimental febrile seizures.Dec 31, 2011

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Pubmed Data : Front Pharmacol. 2019 ;10:566. Epub 2019 May 22. PMID: 31191309

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin attenuated oxidative stress in a COPD model induced by cigarette smoke.Dec 31, 2015

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Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:1698379. Epub 2016 Nov 28. PMID: 28003846

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Chronic Obstructive Pulmonary Disease

Pharmacological Actions : Antioxidants, Nrf2 activation

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Paeoniflorin attenuates cerebral ischemia-induced injury.Feb 26, 2017

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Pubmed Data : Chin Med. 2018 ;13:14. Epub 2018 Mar 20. PMID: 29560022

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Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:152-160. Epub 2017 Jun 27. PMID: 28666238

Article Published Date : Aug 31, 2017

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Inflammation, Ulcerative Colitis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodelling in a model of acute myocardial infarction.Dec 31, 2017

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Pubmed Data : Drug Des Devel Ther. 2018 ;12:823-836. Epub 2018 Apr 12. PMID: 29695894

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

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Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress.Dec 31, 2014

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Pubmed Data : Int J Clin Exp Med. 2015 ;8(4):5103-11. Epub 2015 Apr 15. PMID: 26131083

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Depression, Menopausal Syndrome

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Ovariectomy-Induced Changes

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Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

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Pubmed Data : Food Chem Toxicol. 2012 May ;50(5):1560-7. Epub 2012 Feb 2. PMID: 22326807

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Pubmed Data : Inflammopharmacology. 2019 Jul 15. Epub 2019 Jul 15. PMID: 31309485

Article Published Date : Jul 14, 2019

Study Type : Insect Study

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Substances : Paeoniflorin

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3.May 31, 2018

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Pubmed Data : Acta Pharm. 2018 Jun 1 ;68(2):211-222. PMID: 29702481

Article Published Date : May 31, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Paeoniflorin

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, STAT3 Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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Paeoniflorin is a potential agent against osteolysis-related diseases caused by excessive osteoclast activity.Feb 19, 2018

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Pubmed Data : Med Sci Monit. 2018 Feb 20 ;24:1044-1053. Epub 2018 Feb 20. PMID: 29459582

Article Published Date : Feb 19, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Paeoniflorin, Peony

Diseases : Bone Diseases: Over-Active Osteoclasts

Pharmacological Actions : Anti-Apoptotic, NF-kappaB Inhibitor

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Paeoniflorin is predicted to be a potential therapy for chronic hepatic diseases associated with fibrosis and angiogenesis.Jan 31, 2019

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Pubmed Data : Exp Parasitol. 2019 Feb ;197:85-92. Epub 2018 Nov 8. PMID: 30414842

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Liver Disease, Schistosomiasis

Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Vascular Endothelial Growth Factor Inhibitors

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Paeoniflorin may be a potential neuroprotective agent for stroke.Dec 31, 2014

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Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):42-9. Epub 2014 Nov 20. PMID: 25479726

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Hepatitis: Lectin-Induced (concanavalin)

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Concanavalin A

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Paeoniflorin protects against ischemia-induced brain damages in rats.Dec 31, 2011

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Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora.Dec 31, 2003

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Pubmed Data : Fitoterapia. 2004 Jan ;75(1):45-9. PMID: 14693219

Renal protective effect of Paeoniflorin by inhibition of JAK2/STAT3 signaling pathway in diabetic mice.May 12, 2018

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The upregulation of serotonergic systems may be an important mechanism for the antidepressant-like effects of paeoniflorin.Mar 31, 2013

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Pubmed Data : Exp Ther Med. 2013 Apr ;5(4):1113-1116. Epub 2013 Jan 25. PMID: 23599734

Article Published Date : Mar 31, 2013

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

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Pubmed Data : Life Sci. 2019 Nov 15 ;237:116925. Epub 2019 Oct 11. PMID: 31610201

Article Published Date : Nov 14, 2019

Study Type : Review

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Substances : Paeoniflorin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

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A review of the regulatory effects of paeoniflorin on inflammation and immune diseases.Dec 31, 2018

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Pubmed Data : Pharm Biol. 2014 Sep ;52(9):1189-95. Epub 2014 Mar 19. PMID: 24646307

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Pubmed Data : Front Pharmacol. 2019 ;10:268. Epub 2019 Mar 20. PMID: 30949054

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Paeoniflorin, Peony

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Gastrointestinal Agents

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Neuroprotective effect of paeoniflorin on H2O2-induced apoptosis in PC12 cells.Apr 30, 2015

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Pubmed Data : Inflammation. 2013 Feb ;36(1):216-25. PMID: 23053726

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Lipopolysaccharide-Induced Toxicity

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Pubmed Data : J Cell Biochem. 2018 Nov ;119(10):8636-8642. Epub 2018 Aug 4. PMID: 30076630

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells.Jul 31, 2015

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Pubmed Data : J Cell Biochem. 2018 Oct 28. Epub 2018 Oct 28. PMID: 30368886

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Pubmed Data : Food Funct. 2018 Apr 25 ;9(4):2386-2397. PMID: 29594285

Article Published Date : Apr 24, 2018

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Endothelial Dysfunction, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

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Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-κB activation.Jan 31, 2012

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Pubmed Data : Mol Med Rep. 2012 Feb ;5(2):351-6. Epub 2011 Nov 1. PMID: 22051979

Article Published Date : Jan 31, 2012

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Cancers: Multi-Drug Resistant, Gastric Cancer

Pharmacological Actions : Bcl-2 protein down-regulation, Multidrug Resistance Gene Modulators, NF-kappaB Inhibitor

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Paeoniflorin potentiates the inhibitory effects of erlotinib in pancreatic cancer cell linesJan 08, 2016

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Pubmed Data : Sci Rep. 2016 09 9 ;6:32809. Epub 2016 Sep 9. PMID: 27609096

Article Published Date : Jan 08, 2016

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Chemotherapeutic Synergy: Erlotinib

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Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy.Jul 23, 2017

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Pubmed Data : J Pharmacol Sci. 2015 May ;128(1):8-16. Epub 2015 Feb 27. PMID: 26041080

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Pubmed Data : Front Pharmacol. 2020 ;11:736. Epub 2020 May 15. PMID: 32499710

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : Paeoniflorin

Diseases : Photooxidative Stress, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Photoprotective

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View the Evidence: 204 Abstracts with Paeoniflorin Research

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Paeoniflorin may provide a new therapeutic approach to regulate P2X7R-mediated pathologic responses of primary Sjögren's syndrome.Aug 31, 2015

Anticonvulsive effect of paeoniflorin on experimental febrile seizures.Dec 31, 2011

Application of paeoniflorin represents a novel therapeutic approach for the treatment of cutaneous wounds.Jun 14, 2020

Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia.Jan 14, 2018

Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model.Oct 04, 2019

Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain.Apr 10, 2019

Neuroprotection by paeoniflorin in the MPTP mouse model of Parkinson's disease.Dec 31, 2016

Oral administration of paeoniflorin attenuates allergic contact dermatitis.Mar 31, 2015

Paeonia lactiflora reduced cerebral ischemia and arterial intimal hyperplasia.Dec 31, 2012

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.Dec 31, 2013

Paeoniflorin alleviates H2O2-Induced oxidative injury through down-regulation of microRNA-135a in HT-22 cells.Nov 13, 2019

Paeoniflorin alleviates lipopolysaccharide-induced disseminated intravascular coagulation.May 31, 2020

Paeoniflorin alleviates non-alcoholic steatohepatitis.Aug 31, 2016

Paeoniflorin ameliorates acute myocardial infarction.Aug 31, 2015

Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis‑induced acute renal injury.Jul 31, 2016

Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome.Nov 30, 2017

Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia.Jul 14, 2020

Paeoniflorin ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension.Dec 31, 2019

Paeoniflorin ameliorates chronic stress-induced depression-like behaviours and neuronal damages.Dec 31, 2017

Paeoniflorin ameliorates experimental autoimmune encephalomyelitis.Jan 05, 2017

Paeoniflorin ameliorates fructose-induced insulin resistance and hepatic steatosis.Aug 04, 2018

Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviours.Jan 30, 2017

Paeoniflorin ameliorates liver injury of MRL/lpr mice through inhibition of NF-κB pathway.Oct 31, 2017

Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression.Dec 31, 2015

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balanceMay 28, 2020

Paeoniflorin and albiflorin are potential therapeutic agents for neuropathic pain, which merit further investigation.Dec 31, 2015

Paeoniflorin and albiflorin may promote the recovery of bone marrow hemopoietic function in a myelosuppression model.Dec 31, 2015

Paeoniflorin and astragaloside IV alleviate ischemic brain edema.Aug 31, 2017

Paeoniflorin as a promising therapeutic agent for treating diabetic nephropathy.Dec 31, 2018

Paeoniflorin attenuated oxidative stress in a COPD model induced by cigarette smoke.Dec 31, 2015

Paeoniflorin attenuates cerebral ischemia-induced injury.Feb 26, 2017

Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage.May 16, 2006

Paeoniflorin attenuates depressive behaviors in systemic lupus erythematosus.Jun 30, 2018

Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage.Apr 02, 2020

Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia.Nov 30, 2016

Paeoniflorin attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response.Jul 31, 2013

Paeoniflorin attenuates myocardial fibrosis in isoprenaline-induced chronic heart failure.Mar 31, 2020

Paeoniflorin attenuates postoperative pain by suppressing matrix metalloproteinase-9/2 in mice.Dec 31, 2017

Paeoniflorin attenuates pressure overload-induced cardiac remodeling.May 31, 2013

Paeoniflorin attenuates pulmonary fibrosis by suppressing type I collagen synthesis.Oct 06, 2013

Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosisAug 31, 2011

Paeoniflorin attenuates the vascular injury induced by fluctuant hyperglycemia.Dec 31, 2018

Paeoniflorin can inhibit the radiation induced hepatic fibrosis.Dec 31, 2017

Paeoniflorin can significantly inhibit the pathology of adjuvant arthritis.Jun 30, 2018

Paeoniflorin could ameliorate the symptoms and improve the functional capability of post-stroke depression similar to that of fluoxetine.Apr 30, 2019

Paeoniflorin could attenuate cardiac remodelling and improve cardiac function in chronic heart failure.May 31, 2019

Paeoniflorin could regulate HPA axis dysfunction in a rat model of PTSD.Mar 31, 2020

Paeoniflorin effectively improved cardiac function during endotoxemia.Apr 30, 2016

Paeoniflorin exerts a nephroprotective effect on concanavalin A-induced damage.Jul 24, 2015

Paeoniflorin exerts a neuroprotective effect in model of dementia.Dec 31, 2017

Paeoniflorin exerts analgesic and hypnotic effects via adenosine A1 receptors in a neuropathic pain model.Dec 31, 2015

Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer's disease via activation of adenosine A1 receptor.Apr 30, 2020

Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury.Oct 31, 2018

Paeoniflorin has the anti-inflammatory effect in ulcerative colitis.Aug 31, 2017

Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodelling in a model of acute myocardial infarction.Dec 31, 2017

Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress.Dec 31, 2014

Paeoniflorin improves pressure overload-induced cardiac remodelling by modulating the MAPK signalling pathway in spontaneously hypertensive rats.Feb 28, 2019

Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis.Dec 31, 2009

Paeoniflorin inhibits glioblastoma growth in vivo and in vitro.Dec 31, 2017

Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo.Apr 30, 2012

Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis.Nov 30, 2013

Paeoniflorin inhibits macrophage-mediated lung cancer metastasis.Nov 30, 2015

Paeoniflorin inhibits mesangial cell proliferation and inflammatory response in rats with mesangial proliferative glomerulonephritis.Dec 31, 2018

Paeoniflorin inhibits migration and invasion of human glioblastoma cells.Feb 28, 2018

Paeoniflorin inhibits Rho kinase activation in joint synovial tissues of rats with collagen-induced rheumatoid arthritis.Sep 30, 2018

Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis.Jun 30, 2009

Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities.Jul 14, 2019

Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3.May 31, 2018

Paeoniflorin is a potential agent against osteolysis-related diseases caused by excessive osteoclast activity.Feb 19, 2018

Paeoniflorin is predicted to be a potential therapy for chronic hepatic diseases associated with fibrosis and angiogenesis.Jan 31, 2019

Paeoniflorin may be a potential neuroprotective agent for stroke.Dec 31, 2014

Paeoniflorin may be beneficial for the prevention of lung injury in systemic lupus erythematosus.Apr 30, 2018

Paeoniflorin

View the Evidence:
204 Abstracts with Paeoniflorin Research