Mangiferin

Name	AC	CK
Athletic Performance	1	10
Diabetes Mellitus: Type 2	5	10
Oxidative Stress	4	10
Chemically-Induced Liver Damage	3	8
Inflammation	4	7
Insulin Resistance	4	7
Mercury Poisoning	3	7
Allergies	3	5
Neuropathic Pain	3	5
Arsenic Poisoning	2	4
Cancers: All	4	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Colitis	2	4
Diabetes: Cardiovascular Illness	2	4
Diabetic Nephropathy	2	4
Hyperlipidemia	2	4
Lipopolysaccharide-Induced Toxicity	3	4
Lung Cancer	3	4
Nonalcoholic fatty liver disease (NAFLD)	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Alzheimer's Disease	2	3
Colon Cancer	2	3
Hyperglycemia	2	3
Liver Cancer	2	3
Ovarian Cancer	2	3
Periodontitis	2	3
Tumors	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Alcoholic Liver Disease	1	2
Allodynia	1	2
Aluminum Toxicity	1	2
Anaphylaxis	1	2
Aneurysmal subarachnoid hemorrhage (SAH)	1	2
Arteriosclerosis	1	2
Bone Fractures	1	2
Brain Cancer	2	2
Brain Damage: Hypoxic Ischemic Insult	1	2
Brain Injury: Traumatic	1	2
Brain: Oxidative Stress	1	2
Breast Cancer	2	2
Carcinoma: Non-Small-Cell Lung	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chronic Pain	1	2
Cognitive Decline/Dysfunction	1	2
Colon Polyps	1	2
Depression	1	2
Dermatitis	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetes: Kidney Function	1	2
Gastric Ulcer	1	2
HSV-1	2	2
High Fat Diet	1	2
Hyperalgesia	1	2
Hyperinsulinism	1	2
Hypersensitivity	1	2
Hypertension	1	2
Hyperuricemia	1	2
Immune Disorders: Low Immune Function	1	2
Inflammatory Bowel Diseases	1	2
Iron Overload	1	2
Ischemia	1	2
Ischemia: Myocardial	1	2
Kidney Damage	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Injury: Ischemia/reperfusion	1	2
Neurodegenerative Diseases	2	2
Obesity	1	2
Pain	1	2
Parasitic Diseases	1	2
Prostate Cancer	2	2
Pruritus	1	2
Pulmonary Fibrosis	1	2
Radiation Induced Illness	2	2
Renal Fibrosis	1	2
Renal tubulointerstitial fibrosis	1	2
Sepsis	1	2
Triglycerides: Elevated	1	2
5alpha-dihydrotestosterone (DHT): Elevated Levels/Activity	1	1
Advanced Glycation End products (AGE)	1	1
Air Pollution Linked Toxicity	1	1
Bone Diseases	1	1
Breast Cancer: Triple Negative	1	1
Cadmium Poisoning	1	1
Cervical Cancer	1	1
Diabetic Complications	1	1
Endothelial Dysfunction	1	1
Fibrosarcoma	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
HIV Infections	1	1
HSV-2	1	1
Helicobacter Pylori Infection	1	1
High Sugar Diet	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Mastitis	1	1
Melanoma: Metastatic	1	1
Metabolic Syndrome X	1	1
Mitochondrial Dysfunction	1	1
Multiple Myeloma	1	1
Myocardial Ischemia	1	1
Osteoarthritis	1	1
Osteoporosis	1	1
Promyelocytic leukemia	1	1
Prostatic Hyperplasia: Benign	1	1

Name	AC	CK
Anti-Inflammatory Agents	27	45
Antioxidants	19	33
Hepatoprotective	11	22
Tumor Necrosis Factor (TNF) Alpha Inhibitor	12	22
Hypoglycemic Agents	6	12
Neuroprotective Agents	8	12
Cardioprotective	7	11
Anti-Apoptotic	4	10
Antiproliferative	9	10
Apoptotic	9	10
NF-kappaB Inhibitor	7	10
Interleukin-6 Downregulation	5	8
Anti-metastatic	5	6
Anticarcinogenic Agents	3	6
Cyclooxygenase 2 Inhibitors	4	6
Immunomodulatory	4	6
Interleukin-1 beta downregulation	4	6
Renoprotective	3	6
Analgesics	3	5
Anti-Allergic Agents	3	5
Chemopreventive	4	5
Chemoprotective Agents	3	5
Chemosensitizer	3	5
Chemotherapeutic	4	5
Hypolipidemic	3	5
Nrf2 activation	3	5
Anti-Fibrotic	2	4
Antinoceceptive	2	4
Antiviral Agents	4	4
Cell cycle arrest	3	4
Pancreato Protective Agents	2	4
Anti-Bacterial Agents	3	3
Radioprotective	3	3
Angiotensin-Converting Enzyme Inhibitors	1	2
Anti-Ulcer Agents	1	2
Antidepressive Agents	1	2
Antihypertensive Agents	1	2
Antiparasitic Agents	1	2
Autophagy Inhibitors	1	2
Cytoprotective	2	2
Heme oxygenase-1 up-regulation	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Immunomodulatory: Th17 downregulation	1	2
Immunostimulatory	1	2
Interleukin-18 down-regulation	1	2
Malondialdehyde Down-regulation	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Nitric Oxide Enhancer	1	2
Vasoprotective	1	2
Wnt/β-catenin signaling pathway modulation	2	2
5-alpha reductase inhibitor	1	1
Anti-Angiogenic	1	1
Anti-Glycation Agents	1	1
Anti-HIV Agents	1	1
Anti-pyretic	1	1
Anticholesteremic Agents	1	1
Antimutagenic Agents	1	1
Antineoplastic Agents	1	1
Bcl-2 protein down-regulation	1	1
Enzyme Inhibitors	1	1
Genoprotective	1	1
Interleukin-8 downregulation	1	1
MicroRNA modulator	1	1
Radiosensitizer	1	1
STAT3 Inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Uricosuric Agents	1	1
p300/NF-κB down-regulation	1	1

[+]

Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men.Feb 05, 2019

Pubmed Data : Biomed Pharmacother. 2019 Jun 15 ;117:109097. Epub 2019 Jun 15. PMID: 31212128

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Pubmed Data : Arch Pharm Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31989480

Article Published Date : Jan 26, 2020

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Oxidative Stress, Pre-Eclampsia

Pharmacological Actions : Antioxidants

[+]

Mangiferin attenuated adverse skeletal muscle changes in obese rats.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Res (Stuttg). 2018 Sep 6. Epub 2018 Sep 6. PMID: 30189460

Article Published Date : Sep 05, 2018

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Iron Overload

[+]

Mangiferin could provide a new target for the therapy and prevention of skin inflammation.Feb 17, 2017

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Pubmed Data : Int Immunopharmacol. 2017 Feb 18 ;45:174-179. Epub 2017 Feb 18. PMID: 28222357

Article Published Date : Feb 17, 2017

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Dermatitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Mangiferin enhances endochondral ossification-based bone repair in massive bone defect.Mar 15, 2018

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Pubmed Data : FASEB J. 2018 Mar 16:fj201701411R. Epub 2018 Mar 16. PMID: 29547701

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Pubmed Data : Biomed Chromatogr. 2018 Feb 12. Epub 2018 Feb 12. PMID: 29431198

Article Published Date : Feb 11, 2018

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Sepsis

Pharmacological Actions : Antioxidants

[+]

Mangiferin potentiates neuroprotection by isoflurane in neonatal hypoxic brain injury.Oct 18, 2018

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Pubmed Data : Med Sci Monit. 2018 Oct 19 ;24:7459-7468. Epub 2018 Oct 19. PMID: 30338764

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Pubmed Data : Mol Neurobiol. 2016 Jul 21. Epub 2016 Jul 21. PMID: 27443159

Article Published Date : Jul 20, 2016

Study Type : Animal Study

Additional Links

Substances : Mangiferin, Mango

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Mechanism of anti-dementia effects of mangiferin in a senescence accelerated mouse (SAMP8) model.Sep 03, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Dermatolog Treat. 2020 Feb 3:1-10. Epub 2020 Feb 3. PMID: 32013660

Article Published Date : Feb 02, 2020

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates.May 18, 2020

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Pubmed Data : J Complement Integr Med. 2020 May 19. Epub 2020 May 19. PMID: 32427121

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Pubmed Data : Pharmacol Res. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29305909

Article Published Date : Jan 03, 2018

Study Type : Review

Additional Links

Substances : 4-Shogaol, 6-Shogaol, Apigenin, Berberine, Caffeic Acid, Capsaicin, Cardamonin, Chrysin, Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Fisetin, Gingerol , Luteolin, Mangiferin, Piperlongumine , Polyphenols, Pterostilbene, Quercetin, Resveratrol, Rutin, Sesamin, Ursolic Acid, Wogonin, Xanthohumol

Diseases : Cancers: All

Pharmacological Actions : Chemopreventive, Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, STAT3 Inhibitor, Wnt/β-catenin signaling pathway modulation

[+]

Exosomes derived from mangiferin‑stimulated perivascular adipose tissue ameliorate endothelial dysfunction.May 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Zhong Yao Cai. 2010 Jan;33(1):81-5. PMID: 20518311

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Leukemia, Promyelocytic leukemia

Pharmacological Actions : Antiproliferative , Cell cycle arrest

Additional Keywords : Xanthones

[+]

Mangiferin decreases LPS-induced production of IL-6 in human oral epithelial cells.Aug 03, 2016

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Pubmed Data : Arch Oral Biol. 2016 Aug 4 ;71:155-161. Epub 2016 Aug 4. PMID: 27517515

Article Published Date : Aug 03, 2016

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Lipopolysaccharide-Induced Toxicity, Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Click here to read the entire abstract

Pubmed Data : Biofactors. 2016 May 24. Epub 2016 May 24. PMID: 27219011

Article Published Date : May 23, 2016

Study Type : Review

Additional Links

Substances : Mangiferin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Mangiferin has potent antitumor, immunomodulatory and anti-HIV activity. Nov 01, 2009

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Pubmed Data : J Obstet Gynaecol. 2009 Nov;29(8):681-5. PMID: 8957579

Mangiferin may be a potential therapeutic agent with a new mechanism of targeting NIK for the treatment of metastatic melanoma.Aug 31, 2016

Mangiferin relieves lipopolysaccharide-induced injury by up-regulating miR-181a via targeting PTEN in ATDC5 cells.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jun 28. PMID: 27367721

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Article Publish Status : This is a free article. Click here to read the complete article.

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View the Evidence: 135 Abstracts with Mangiferin Research

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Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men.Feb 05, 2019

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

A significant reduction in blood glucose and HbA1c levels was observed in rats treated with resveratrol or mangiferin.Jul 08, 2018

Anti-allodynic effect of mangiferin in rats with chronic post-ischemia pain.Dec 31, 2017

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma.Oct 21, 2019

Anti-neoplastic effect of mangiferin on human ovarian adenocarcinoma OVCAR8 cells.Dec 31, 2018

Isolated mangiferin and naringenin exert antidiabetic effects.Jan 24, 2018

Mangifera indica and mangiferin has anti-parasitic and anti-allergic activities.Dec 01, 2003

Mangifera indica exhibits ant-inflammatory properties.Aug 01, 2004

Mangifera indica has immunomodulatory activity in mice. Dec 01, 2001

Mangiferin activates lymphocytes in normal and tumor bearing mice. Nov 01, 1987

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.Apr 26, 2020

Mangiferin alleviates arsenic induced oxidative lung injury.Feb 11, 2019

Mangiferin alleviates hypertension induced by hyperuricemia.Jun 05, 2018

Mangiferin alleviates ovalbumin-induced allergic rhinitis.May 11, 2020

Mangiferin alleviates renal interstitial fibrosis in streptozotocin-induced diabetic mice.Dec 31, 2019

Mangiferin ameliorated hyperlipidemia by intervening in some major metabolic pathway.Jul 18, 2017

Mangiferin ameliorates acetaminophen-induced hepatotoxicity.Jun 14, 2019

Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation.Oct 08, 2017

Mangiferin ameliorates gestational diabetes mellitus-induced placental oxidative stress, inflammation.Sep 14, 2019

Mangiferin ameliorates hyperuricemic nephropathy which is associated with downregulation of AQP2 and increased urinary uric acid excretion.Dec 31, 2019

Mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in mouse model of preeclampsia.Jan 26, 2020

Mangiferin attenuated adverse skeletal muscle changes in obese rats.Dec 31, 2016

Mangiferin attenuated diethynitrosamine-induced hepatocellular carcinoma.Dec 31, 2018

Mangiferin attenuates blast-induced traumatic brain injuryApr 24, 2017

Mangiferin attenuates bleomycin-induced pulmonary fibrosis.Mar 06, 2019

Mangiferin attenuates cisplatin-induced acute kidney injury.Aug 05, 2018

Mangiferin could increase urinary iron excretion and to decrease iron accumulation in liver and heart.Sep 05, 2018

Mangiferin could provide a new target for the therapy and prevention of skin inflammation.Feb 17, 2017

Mangiferin enhances endochondral ossification-based bone repair in massive bone defect.Mar 15, 2018

Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure.May 14, 2020

Mangiferin exhibits anti-diabetic properties.Mar 01, 2001

Mangiferin has a protective role on arsenic induced hepatotoxicity.Mar 27, 2016

Mangiferin has anti-inflammatory and analgesic properties when locally administrated.Jul 04, 2018

Mangiferin has anti-inflammatory effects on periodontitis.Jan 29, 2016

Mangiferin improved palmitate-induced-insulin resistance.Dec 31, 2018

Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis.May 29, 2019

Mangiferin improves hepatic lipid metabolism.Dec 31, 2017

Mangiferin induces islet regeneration in aged mice.Feb 28, 2018

Mangiferin inhibits apoptosis and oxidative stress caused by dexamethasone.Apr 30, 2018

Mangiferin inhibits bowel carcinogenesis in male rats.Feb 26, 2001

Mangiferin inhibits high-fat diet induced vascular injury via regulation of PTEN/AKT/eNOS pathway.Jun 30, 2018

Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects.Apr 12, 2017

Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice.Oct 01, 2009

Mangiferin is neuroprotective against early brain injury after subarachnoid hemorrhage.Sep 18, 2017

Mangiferin is potent anti-inflammatory compound that reduces inflammation.Feb 19, 2017

Mangiferin may ameliorate colitis by the restoration of disturbed Th17/Treg cells and inhibition of macrophage activation.Apr 30, 2016

Mangiferin may be considered a potential antineoplastic drug for the future treatment of cancer.Mar 31, 2016

Mangiferin may be of value in the prevention of benzo(a)pyrene-induced lung carcinogenesis.Sep 01, 2003

Mangiferin may reduce toxicity associated with hyperglycemia and atherogenicity in diabetic rats.May 01, 2001

Mangiferin plays a protective role in moderation of sepsis-induced lung injury.Feb 11, 2018

Mangiferin potentiates neuroprotection by isoflurane in neonatal hypoxic brain injury.Oct 18, 2018

Mangiferin prevents diabetic nephropathy progression and protects podocyte function.Apr 04, 2018

Mangiferin prevents diabetic nephropathy progression in diabetic rats. Jul 30, 2010

Mangiferin protects against myocardial IR injury by modulating MAPK mediated inflammation and apoptosis. Apr 04, 2016

Mangiferin protects against ‭intestinal ischemia/reperfusion-induced ‭liver injuryMay 11, 2017

Mangiferin protects rats against aluminum chloride induced neurotoxicity.Jun 30, 2015

Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats.Jul 15, 2002

Mangiferin reduces colonic damage in a murine model of colitis.Jun 24, 2016

Mangiferin shows synergistic anticancer activity with cisplatin.Dec 31, 2017

Mangiferin suppresses blood lipids in type 2 diabetes. Oct 01, 2000

Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium.Mar 26, 2017

Mango leaves hae antioxidant and antiulcerogenic action.Jan 01, 2009

Mango may provide a useful tool to target different aspects of Alzheimer's disease pathology.Jul 20, 2016

Mechanism of anti-dementia effects of mangiferin in a senescence accelerated mouse (SAMP8) model.Sep 03, 2019

Positive interaction of mangiferin with selected oral hypoglycemic drugs.May 24, 2020

The anti-allodynic effect induced by mangiferin is mediated at least in part by the serotoninergic system.Oct 27, 2016

The Ayurvedic medicine Salacia oblonga (and the compound mangiferin) attenuates diabetic renal fibrosis in rats.Aug 25, 2009

The overall results suggest that combination of mangiferin with both metformin and gliclazide alleviates diabetic conditions.Mar 21, 2019

The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.May 31, 2017

Therapeutic effects of mangiferin on sepsis-associated acute lung and kidney injuries.Jun 11, 2020

These data suggest that the gabapentin and mangiferin combination produces a synergistic interaction at the peripheral level.Nov 30, 2017

Mangiferin

View the Evidence:
135 Abstracts with Mangiferin Research