Luteolin

Name	AC	CK
Inflammation	15	28
Lipopolysaccharide-Induced Toxicity	12	20
Oxidative Stress	11	18
Nonalcoholic fatty liver disease (NAFLD)	3	14
Brain Inflammation	9	13
Cardiovascular Diseases	3	13
Lung Cancer	10	13
Metabolic Syndrome X	2	12
Alzheimer's Disease	7	11
Liver Cancer	8	11
Athletic Performance	1	10
Cancers: All	10	10
Colon Cancer	9	10
Breast Cancer	8	9
Colorectal Cancer	7	8
Breast Cancer: Triple Negative	6	7
Cancers: Drug Resistant	5	7
Hyperglycemia	2	7
Insulin Resistance	4	7
Ischemia	2	7
Obesity	4	7
Chemically-Induced Liver Damage	3	6
Coronavirus Infection	6	6
Escherichia coli Infections	2	6
Gastric Cancer	5	6
Lead Poisoning	3	6
Myocardial Ischemia	3	6
Urinary Tract Infections	2	6
Carcinoma: Non-Small-Cell Lung	4	5
Diabetic Complications	1	5
Hypercholesterolemia	3	5
Melanoma	3	5
Memory Disorders	3	5
Multiple Sclerosis	3	5
Ovarian Cancer	4	5
Anxiety Disorders	2	4
Atherosclerosis	2	4
Autism Spectrum Disorders	2	4
Bisphenol Toxicity	2	4
Colitis	2	4
Depression	2	4
Endothelial Dysfunction	3	4
Fibrosis	2	4
Hepatic Steatosis	2	4
Learning disorders	2	4
Neurodegenerative Diseases	3	4
Prostate Cancer	3	4
Sepsis	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Allergic Rhinitis	2	3
Brain: Microglial Activation	3	3
Cancer Metastasis	2	3
Cognitive Decline/Dysfunction	2	3
Diabetic Nephropathy	2	3
Glioblastoma	3	3
Parkinson's Disease	2	3
Periodontal Diseases	2	3
Tumors	3	3
Acetaminophen (Tylenol) Toxicity	1	2
Advanced Glycation End products (AGE)	2	2
Anxiety	1	2
Arthritis	1	2
Autism	1	2
Brain: Oxidative Stress	1	2
Cardiomyopathy	1	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Toxicity: Cisplatin	2	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Irinotecan	1	2
Chikungunya Virus	2	2
Chronic Pain	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes Mellitus: Type 2	2	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Cognitive Dysfunction	1	2
Down Syndrome	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Dyslipidemias	1	2
Electromagnetic Radiation Mitigation	1	2
Endometriosis	1	2
Enterovirus 71	1	2
Epilepsy	1	2
Esophageal Cancer	2	2
Fluoride Toxicity	1	2
Hashimoto's thyroiditis	1	2
Heart Failure	1	2
Hepatoma	2	2
Hydrogen Peroxide Induced Toxicity	2	2
Intracerebral Hemorrhage	1	2
Kidney Cancer	1	2
Kidney Damage	1	2
Kidney Damage: Chemically-Induced	1	2
Liver Cirrhosis	1	2
Liver Failure: Acute	1	2
Liver Fibrosis	1	2
Lung Cancer: Prevention	1	2
Lung Injury: Acute	1	2
Mercury Poisoning	1	2
Mood Disorders	1	2
Mucositis	1	2
Pancreatic Cancer	2	2
Pneumonia	1	2
Postmenopausal Disorders: Weight Gain/Obesity	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Promyelocytic leukemia	2	2
Sleep Disorders	1	2
Spinal Cord Injuries	1	2
Adiponectin: Low Levels	1	1
Bladder Cancer	1	1
Brain Ischemia	1	1
Breast Cancer: Lung Metastasis	1	1
Cancers: Canine	1	1
Cardiac Hypertrophy	1	1
Central Nervous System Diseases	1	1
Cholesterol: Oxidation	1	1
Choriocarcinoma	1	1
Chronic Lymphocytic Leukemia	1	1
Coronavirus Disease	1	1
Endothelial Damage	1	1
Excitotoxicity	1	1
Gastrointestinal Inflammation	1	1
Glioma	1	1
Gout	1	1
HIV Infections	1	1
Heavy Metal Toxicity	1	1
Hyperinsulinism	1	1
Hyperuricemia	1	1
Hypoxia	1	1
Inflammatory Bowel Diseases	1	1
Influenza A	1	1
Keloid	1	1
Leishmaniasis	1	1
Leukemia	1	1
Listeria Infections	1	1
Lyme Borreliosis	1	1
Lyme Disease	1	1
Mitochondrial Dysfunction	1	1
Multiple Myeloma	1	1
Osteoarthritis	1	1
Osteoporosis	1	1
Psoriasis	1	1
Severe Acute Respiratory Syndrome	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Thyroid Cancer	1	1
Tongue Cancer	1	1
Ultraviolet Radiation Induced Damage	1	1
Weight Problems	1	1

Name	AC	CK
Anti-Inflammatory Agents	56	98
Antioxidants	45	78
Apoptotic	56	63
Antiproliferative	44	51
Neuroprotective Agents	28	44
Interleukin-6 Downregulation	22	40
Nrf2 activation	19	35
Tumor Necrosis Factor (TNF) Alpha Inhibitor	17	32
Cardioprotective	13	31
Hepatoprotective	8	27
Anti-metastatic	17	23
Interleukin-1 beta downregulation	12	20
NF-kappaB Inhibitor	11	20
Renoprotective	7	14
MicroRNA modulator	10	13
Antineoplastic Agents	9	12
Cell cycle arrest	11	12
Heme oxygenase-1 up-regulation	6	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	7	10
Anti-Apoptotic	7	9
Antiviral Agents	8	9
Chemopreventive	7	9
Chemosensitizer	7	8
Chemotherapeutic	7	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	8
Anti-Bacterial Agents	2	6
Anti-Fibrotic	3	6
Anticarcinogenic Agents	4	6
Autophagy Up-regulation	4	6
Malondialdehyde Down-regulation	3	6
Cyclooxygenase 2 Inhibitors	5	5
Enzyme Inhibitors	5	5
Immunomodulatory	4	5
STAT3 Inhibitor	4	5
Tumor Suppressor Protein p53 Upregulation	4	5
Angiogenesis Inhibitors	3	4
Antidepressive Agents	2	4
Chemoprotective Agents	2	4
Gastroprotective	2	4
P21 Activation	3	4
Radioprotective	2	4
Superoxide Dismutase Up-regulation	2	4
Wnt/β-catenin signaling pathway modulation	4	4
Anticholesteremic Agents	2	3
Antimicrobial	3	3
Hypoglycemic Agents	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	3	3
Interferon Gamma Reducer	2	3
Interleukin-10 upregulation	2	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Anti-Anxiety Agents	1	2
Anticonvulsants	1	2
Antinoceceptive	1	2
Anxiolytic	1	2
Autophagy Inhibitors	2	2
Bcl-2 protein down-regulation	2	2
Brain-derived neurotrophic factor modulator	1	2
C-Jun N-Terminal Kinases (JNK) Modulator	1	2
Cyclin D1 Down-Regulation	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Hypnotics and Sedatives	1	2
Hypolipidemic	1	2
Hypoxia-inducible factor-1 (HIF-1) inhibitor	2	2
Immunosuppressive Agents	1	2
Interleukin-2 Downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-4 upregulation	1	2
Interleukin-8 downregulation	2	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
Neurogenesis	1	2
Osteoprotective	1	2
Pancreato Protective Agents	1	2
Proteasome Inhibitors	2	2
Regenerative	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor A Inhibitor	2	2
anti-inflammatory	1	2
Alpha-glucosidase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Angiogenic	1	1
Anti-Glycation Agents	1	1
Cytoprotective	1	1
Cytotoxicity	1	1
Gastrointestinal Agents	1	1
Heat Shock Protein Down-Regulation	1	1
Interferon Inducers	1	1
Neuritogenic	1	1
Nitric Oxide Inhibitor	1	1
Photoprotective	1	1
Radiosensitizer	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Vasodilator Agents	1	1
Xanthine oxidase inhibitor	1	1

[+]

Altilix supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in metabolic syndrome subjects.Oct 24, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Jan 11 ;68:171-178. Epub 2019 Jan 11. PMID: 30641432

Article Published Date : Jan 10, 2019

Study Type : Animal Study

Additional Links

Substances : Apigenin, Chrysin, Luteolin

Diseases : Liver Failure: Acute

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation

[+]

Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2016 ;7:47. Epub 2016 Mar 8. PMID: 27014061

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Luteolin, Palmitoylethanolamide

Diseases : Spinal Cord Injuries

Pharmacological Actions : Neuroprotective Agents, Regenerative

Additional Keywords : regen

[+]

Combination of curcumin and luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice.Aug 14, 2019

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Pubmed Data : J Nutr Biochem. 2019 Aug 15 ;73:108222. Epub 2019 Aug 15. PMID: 31665675

Article Published Date : Aug 14, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin, Luteolin

Diseases : Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

Combination of luteolin and lycopene effectively protect against nonalcoholic fatty liver disease.Jun 19, 2020

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Pubmed Data : Life Sci. 2020 Jun 20 ;256:117990. Epub 2020 Jun 20. PMID: 32574665

Article Published Date : Jun 19, 2020

Study Type : Animal Study

Additional Links

Substances : Luteolin, Lycopene

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

[+]

Dietary luteolin protects against mercuric chloride induced renal injury.Nov 08, 2017

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Pubmed Data : Nutrients. 2018 Oct 3 ;10(10). Epub 2018 Oct 3. PMID: 30282902

Article Published Date : Oct 02, 2018

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Fibrosis, Hepatic Steatosis, Insulin Resistance, Obesity

Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents

Additional Keywords : Anti-Obesity Agents

[+]

Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro.Nov 23, 2010

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Pubmed Data : J Agric Food Chem. 2010 Nov 24 ;58(22):11653-61. Epub 2010 Oct 19. PMID: 20958047

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Pubmed Data : Antioxidants (Basel). 2019 Dec 21 ;9(1). Epub 2019 Dec 21. PMID: 31877779

Article Published Date : Dec 20, 2019

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Chemically-Induced Liver Damage, Lead Poisoning

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Lead

[+]

Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

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Pubmed Data : J Food Biochem. 2020 Jun 29:e13358. Epub 2020 Jun 29. PMID: 32598492

Article Published Date : Jun 28, 2020

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Hypercholesterolemia, Obesity

Pharmacological Actions : Anticholesteremic Agents, Hypoglycemic Agents

[+]

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.Mar 31, 2019

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Luteolin may be a promising lead for the treatment of drug-induced gastroenteropathy.Aug 04, 2020

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Pubmed Data : Drug Chem Toxicol. 2020 Aug 5:1-13. Epub 2020 Aug 5. PMID: 32757682

Article Published Date : Aug 04, 2020

Study Type : Animal Study

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Pubmed Data : IUBMB Life. 2019 Sep ;71(9):1401-1408. Epub 2019 Jun 11. PMID: 31185137

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Multiple Sclerosis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents

[+]

Luteolin may represent a promising candidate for the treatment of intracerebral hemorrhage-induced secondary brain injury.Dec 31, 2018

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Pubmed Data : IUBMB Life. 2020 Jun 1. Epub 2020 Jun 1. PMID: 32478470

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Pubmed Data : AANA J. 2009 Feb;77(1):33-6. PMID: 19263826

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Luteolin, Melissa (Lemonbalm)

Diseases : Anxiety Disorders

Pharmacological Actions : Anxiolytic

[+]

Luteolin-supplemented diets ameliorates bisphenol A-induced toxicity.Jun 02, 2020

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Pubmed Data : Food Chem Toxicol. 2020 Jun 3 ;142:111478. Epub 2020 Jun 3. PMID: 32504732

Protective effects of luteolin on nephrotoxicity induced by long-term hyperglycaemia.Mar 31, 2020

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Pubmed Data : Biomol Ther (Seoul). 2019 Nov 1 ;27(6):584-590. PMID: 31646844

Article Published Date : Oct 31, 2019

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Sleep Disorders

Pharmacological Actions : Hypnotics and Sedatives

[+]

Systemic administration of luteolin promotes wound restoration by ameliorating inflammation and oxidative stress.Jun 29, 2021

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Pubmed Data : Med Sci Monit. 2016 Dec 28 ;22:5173-5180. Epub 2016 Dec 28. PMID: 28029146

Article Published Date : Dec 27, 2016

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Renoprotective

[+]

Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor.May 31, 2020

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Pubmed Data : Antioxidants (Basel). 2020 Mar 5 ;9(3). Epub 2020 Mar 5. PMID: 32150935

Article Published Date : Mar 04, 2020

Study Type : Review

Additional Links

Substances : Luteolin, Palmitoylethanolamide

Diseases : Brain Inflammation , Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Antimicrobial mechanism of luteolin against Staphylococcus aureus and Listeria monocytogenes and its antibiofilm properties.Feb 10, 2020

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Pubmed Data : Microb Pathog. 2020 Feb 11 ;142:104056. Epub 2020 Feb 11. PMID: 32058023

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Pubmed Data : Thyroid. 1999 Apr;9(4):369-76. PMID: 10319943

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Pubmed Data : J Biol Regul Homeost Agents. 2021 06 8 ;35(3). Epub 2021 Jun 8. PMID: 34100279

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Pubmed Data : Cell Death Dis. 2019 Mar 4 ;10(3):218. Epub 2019 Mar 4. PMID: 30833546

Article Published Date : Mar 03, 2019

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemotherapeutic

[+]

Differential effects of luteolin and its glycosides on invasion and apoptosis in MDA-MB-231 triple-negative breast cancer cells.Dec 31, 2018

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Pubmed Data : Curr Pharm Des. 2020 May 26. Epub 2020 May 26. PMID: 32452323

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Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876

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Pubmed Data : Molecules. 2019 Feb 12 ;24(3). Epub 2019 Feb 12. PMID: 30759846

Article Published Date : Feb 11, 2019

Study Type : In Vitro Study

Additional Links

Substances : Luteolin, Thistle

Diseases : Alzheimer's Disease, Diabetes Mellitus: Type 2

Pharmacological Actions : Alpha-glucosidase inhibitor , Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

low concentration of luteolin attenuates doxorubicin-induced cytotoxicity to MCF-7 cells through a combination of antioxidant activity and an increase in levels of Bcl-2 protein. Dec 31, 2014

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Pubmed Data : Eur J Pharmacol. 2011 Apr 15. Epub 2011 Apr 15. PMID: 21513709

Article Published Date : Apr 15, 2011

Study Type : In Vitro Study

Additional Links

Substances : Chicoric Acid, Dandelion , Luteolin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

[+]

Luteolin and kaempferol are a good candidate for the complementary therapeutic agent against liver cancer.Apr 30, 2018

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Pubmed Data : Nutr Cancer. 2018 May-Jun;70(4):594-604. Epub 2018 Apr 25. PMID: 29693446

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Pubmed Data : Brain Res. 2015 Dec 10 ;1629:85-93. Epub 2015 Oct 22. PMID: 26471408

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Pubmed Data : Cytotechnology. 2010 Feb 17. Epub 2010 Feb 17. PMID: 20162352

Article Published Date : Feb 17, 2010

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Osteoporosis

[+]

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Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Oct ;26(5):1425-1429. PMID: 30295262

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Inhibitors

Additional Keywords : Dose Response

[+]

Luteolin inhibits viral-induced inflammatory response in RAW264.7 cells Mar 22, 2016

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Pubmed Data : Free Radic Biol Med. 2016 Mar 23. Epub 2016 Mar 23. PMID: 27016074

Article Published Date : Mar 22, 2016

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Nitric Oxide Inhibitor, Nrf2 activation

[+]

Luteolin is a potential therapeutic candidate for melanoma.Jan 16, 2019

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Pubmed Data : Phytother Res. 2019 Jan 17. Epub 2019 Jan 17. PMID: 30653763

Article Published Date : Jan 16, 2019

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor

[+]

Luteolin is expounded to have great potential to target various genes and pathways to perform anti-inflammatory effects.Jun 23, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Jun 24 ;86:106727. Epub 2020 Jun 24. PMID: 32593158

Pubmed Data : J Neuroinflammation. 2009;6:29. Epub 2009 Oct 13. PMID: 19825165

Article Published Date : Jan 01, 2009

Study Type : Commentary

Additional Links

Substances : Luteolin

Diseases : Multiple Sclerosis

[+]

Luteolin plays an important role in the treatment of human choriocarcinoma cells.Aug 30, 2016

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Pubmed Data : Biol Reprod. 2016 Aug 31. Epub 2016 Aug 31. PMID: 27580988

Article Published Date : Aug 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Choriocarcinoma

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Natural Substance/Drug Synergy

[+]

Pubmed Data : J Med Food. 2008 Jun;11(2):230-6. PMID: 18598163

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Apoptotic

[+]

Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis.Apr 23, 2019

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Pubmed Data : Oncol Res. 2019 Jul 12 ;27(7):773-778. Epub 2018 Mar 14. PMID: 29540256

Article Published Date : Jul 11, 2019

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

[+]

Luteolin, quercetin, genistein and quercetagetin inhibit the effects of lipopolysaccharide.Dec 31, 2016

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Pubmed Data : Cell Mol Biol Lett. 2017 ;22:19. Epub 2017 Sep 4. PMID: 28878808

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Genistein, Luteolin, Quercetin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

[+]

Luteolin-loading of her-2-poly nanoparticles and proliferative inhibition of gastric cancer cells.Dec 31, 2019

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Pubmed Data : J Mol Model. 2021 Jul 8 ;27(8):221. Epub 2021 Jul 8. PMID: 34236507

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Pubmed Data : Pharmacol Res. 2020 Feb ;152:104579. Epub 2019 Nov 30. PMID: 31790820

Article Published Date : Jan 31, 2020

Study Type : Review

Additional Links

Substances : Luteolin, Omega-3 Fatty Acids, Probiotics, Sulforaphane

Diseases : Autism Spectrum Disorders

Pharmacological Actions : Gastrointestinal Agents

[+]

Phytochemicals and micronutrients may enhance efficacy of doxycycline in combating all the morphological forms of studied Borrelia sp.Dec 31, 2015

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Pubmed Data : Int J Biol Sci. 2016 ;12(9):1093-103. Epub 2016 Jul 22. PMID: 27570483

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Baicalein, Iodine, Luteolin, Rosmarinic acid, Vitamin C, Vitamin D

Diseases : Lyme Borreliosis, Lyme Disease

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substance/Drug Synergy

[+]

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Pubmed Data : Environ Health Prev Med. 2010 Jan;15(1):18-26. PMID: 19960424

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Luteolin, Reseda luteola

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Results from this study may provide the possible molecular mechanisms underlying cardiovascular protective effects of luteolin. Jun 08, 2020

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2020 Jun 9 ;30(6):1032-1043. Epub 2020 Mar 9. PMID: 32402583

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View the Evidence: 260 Abstracts with Luteolin Research

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Altilix supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in metabolic syndrome subjects.Oct 24, 2019

Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men.Feb 05, 2019

Olfactory rehabilitation and Palmitoylethanolamide +Luteolin oral supplement might prevent SARS-CoV-2 associated olfactory impairment.Dec 31, 2020

Apigenin and Luteolin significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their anti-inflammatory effects.Apr 21, 2015

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Luteolin and apigenin derived glycosides from Alphonsea elliptica abrogate LPS-induced inflammatory responses in human plasma.Apr 19, 2021

Luteolin decreased the attachment and invasion of uropathogenic escherichia coli in bladder epithelial cells, attenuated UPEC-induced cytotoxicity and biofilm formation.Sep 30, 2014

Luteolin prevents angiotensin II-induced cardiac remodeling.Jan 01, 2015

Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism.Oct 01, 2018

Palmitoylethanolamide and luteolin in combination could have beneficial effects in autism.Dec 31, 2016

Ameliorative effects of luteolin against endometriosis progression.Mar 02, 2019

Antiviral efficacy of flavonoids against enterovirus 71 infection.Jul 06, 2019

Anxiolytic effects of the flavonoid luteolin in a mouse model of acute colitisDec 25, 2019

Apigenin has good hepatoprotective effects and potential as a promising therapeutic agent for acute liver failure in clinical application.Jan 10, 2019

Co-ultramicronized palmitoylethanolamide and luteolin promotes neuronal regeneration after spinal cord injury.Dec 31, 2015

Combination of curcumin and luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice.Aug 14, 2019

Combination of luteolin and lycopene effectively protect against nonalcoholic fatty liver disease.Jun 19, 2020

Dietary luteolin protects against mercuric chloride induced renal injury.Nov 08, 2017

Effects of verbascoside and luteolin on oxidative damage in brain of heroin treated mice.Jun 30, 2005

Flavonoids could be used as protective agents against oxidative stress induced by gentamicin.Jul 31, 2018

Flavonoids may act as a prenatal preventive against increased interleukin-6 mediated maternal immune activiation associated with abnormal social interactions in adult offspring. Dec 10, 2009

Long-term supplementation with a luteolin enriched artichoke leaf extract can prevent adiposity and related metabolic disorders.Jul 26, 2018

Low dose of luteolin activates Nrf2 in the liver of mice.Dec 31, 2019

Luteolin activates Tregs to promote IL-10 expression and alleviating caspase-11-dependent pyroptosis in sepsis-induced lung injury.Jul 07, 2021

Luteolin alleviates cognitive impairment in Alzheimer's disease model.Jul 14, 2021

Luteolin alleviates LPS-induced bronchopneumonia injury in vitro and in vivoJul 29, 2018

Luteolin alleviates myocardial ischemia reperfusion injury.Jun 12, 2020

Luteolin ameliorated the myocardium fibrosis of heart failure.Jan 22, 2017

Luteolin ameliorates diet-induced obesity and its comorbidities.Oct 02, 2018

Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro.Nov 23, 2010

Luteolin ameliorates ferric nitrilotriacetic acid induced renal toxicity and tumor promotional response in rat.May 01, 2009

Luteolin ameliorates testis injury and blood-testis barrier disruption.Mar 28, 2019

Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinomaAug 31, 2019

Luteolin attenuates acute lung injury in experimental mouse model of sepsis.Apr 10, 2018

Luteolin attenuates allergic nasal inflammation.Dec 31, 2019

Luteolin attenuates cardiac ischemia/reperfusion injury in diabetic animals.Dec 31, 2018

Luteolin attenuates diabetic nephropathy through suppressing inflammatory response and oxidative stress.Jan 01, 2020

Luteolin attenuates doxorubicin-induced cardiotoxicity.Dec 31, 2019

Luteolin attenuates sepsis‑induced myocardial injury.Apr 30, 2020

Luteolin can be a chemotherapeutic agent against colorectal cancer.Oct 31, 2014

Luteolin can reduce the inflammatory response of acute gouty arthritis.Feb 27, 2020

Luteolin confers renoprotection against ischemia-reperfusion injury.May 13, 2019

Luteolin could ameliorate the cognitive dysfunctions in streptozotocin-induced diabetic rat model.Aug 06, 2018

Luteolin could be a promising candidate molecule for atherosclerosis.Dec 31, 2018

Luteolin could diminish lead overload in hepatic tissues.Dec 20, 2019

Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

Luteolin decreases atherosclerosis in LDL receptor-deficient mice.Aug 31, 2018

Luteolin effectively suppressed metastases of breast cancer by reversing epithelial-mesenchymal transition.Jan 31, 2017

Luteolin had a protective effect against acetaminophen-induced liver injury in mice.Jun 30, 2015

Luteolin had an anticonvulsant effect in an acute pentylenetetrazole model.Nov 30, 2017

Luteolin has a protective and regenerative effecct against chemically-induced liver fibrosis. Dec 15, 2009

Luteolin improves hypercholesterolemia and glucose intolerance. Jun 28, 2020

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.Mar 31, 2019

Luteolin inhibits invasion of prostate cancer cells. Jun 01, 2009

Luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia and may be useful for mitigating neuroinflammation.May 26, 2008

Luteolin inhibits melanoma growth in vitro and in vivo.Jun 30, 2020

Luteolin inhibits proliferation and induces apoptosis of human melanoma cells.Jan 20, 2019

Luteolin may be a potential candidate for NSCLC therapy, especially for treatment of patients with acquired erlotinib-resistant NSCLC.May 31, 2014

Luteolin may be a promising lead for the treatment of drug-induced gastroenteropathy.Aug 04, 2020

Luteolin may have potential as a therapeutic agent for treating NAFLD.Nov 21, 2016

Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA in H22 hepatoma cells. Dec 31, 2014

Luteolin may provide a promising preclinical therapeutic line in multiple sclerosis being anti-inflammatory, antiapoptotic, and neurotrophic agent.Aug 31, 2019

Luteolin may represent a promising candidate for the treatment of intracerebral hemorrhage-induced secondary brain injury.Dec 31, 2018

Luteolin may serve as an effective anti-tumor drug in gastric cancer treatment.Feb 26, 2017

Luteolin may suppress experimental colitis through the Nrf2 signaling pathway.Aug 24, 2016

Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice.Jan 31, 2014

Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways.Jul 15, 2021

Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment.Jul 11, 2021

Luteolin modulates the NF-E2-related factor 2/glutamate-cysteine ligase pathway in rats with spinal cord injury.Feb 28, 2021

Luteolin possess potent anti-nociceptive and anti-inflammatory properties and can thus be used in pain management.Dec 31, 2017

Luteolin prevents intestinal mucositis induced by irinotecan.Jan 23, 2020

Luteolin prevents systemic metabolic alterations and vascular dysfunction associated with obesity.Dec 31, 2017

Luteolin

View the Evidence:
260 Abstracts with Luteolin Research